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chore: trigger release process #3
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Commits on May 29, 2024
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fix(susie_finemapper): fix in the fine-mapper in case of sum stat imp…
…utation is False (opentargets#627) * fix(susie_finemapper): fix in the FMer in case ss_imp=False * fix: small fix in docs
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Commits on May 30, 2024
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fix(SummaryStatistics): fix in sanity_filter (opentargets#623)
* fix(SummaryStatistics): fix in sanity_filter * fix: adding prune of inf values * fix(dataset): removal of inf values from beta and stderr * fix: fix in test and sanity filter --------- Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: Szymon Szyszkowski <[email protected]>
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build(deps): use pandas[gcp, parquet] (opentargets#626)
Co-authored-by: Yakov <[email protected]>
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Commits on May 31, 2024
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fix(docs): fixed typo in l2g_prediciton schema page (opentargets#629)
Co-authored-by: Szymon Szyszkowski <[email protected]>
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Commits on Jun 4, 2024
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feat(config): extract gwas_significance parameter to step configurati…
…on (opentargets#628) * feat(clumping): lower p-value significance threshold for clumping step * feat(config): extract gwas_significance to config * feat(config): synced p-value in association parsing --------- Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: Yakov <[email protected]>
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Commits on Jun 6, 2024
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feat(data_release): preparation for 24.06 data release (opentargets#633)
* feat(airflow): drop finngen PICS results from etl * feat(l2g): allow to publish feature matrix * fix(types): typo in types * chore(data_release): bumped release date --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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build(deps): bump typing-extensions from 4.11.0 to 4.12.1 (opentarget…
…s#632) Bumps [typing-extensions](https://github.com/python/typing_extensions) from 4.11.0 to 4.12.1. - [Release notes](https://github.com/python/typing_extensions/releases) - [Changelog](https://github.com/python/typing_extensions/blob/main/CHANGELOG.md) - [Commits](python/typing_extensions@4.11.0...4.12.1) --- updated-dependencies: - dependency-name: typing-extensions dependency-type: direct:production update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: Szymon Szyszkowski <[email protected]>
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build(deps-dev): bump pep8-naming from 0.13.3 to 0.14.1 (opentargets#616
) Bumps [pep8-naming](https://github.com/PyCQA/pep8-naming) from 0.13.3 to 0.14.1. - [Release notes](https://github.com/PyCQA/pep8-naming/releases) - [Changelog](https://github.com/PyCQA/pep8-naming/blob/main/CHANGELOG.rst) - [Commits](PyCQA/pep8-naming@0.13.3...0.14.1) --- updated-dependencies: - dependency-name: pep8-naming dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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feat(qtl): ingest credible sets from single cell derived QTLs (openta…
…rgets#630) * chore: prototype ingestion of sceqtls * chore: use credible sets from ftp * feat(study_index): rename tissuefromsourceid to biosamplefromsourceid to accommodate cell type ids * chore: update output paths to final destination
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feat(spark-helpers): enforce schema of returned objects (opentargets#617
) * feat(spark-helpers): enforce schema of returned objects by other function * fix: fixing docstring * test: adding test for array sorter * chore: pre-commit auto fixes [...] * fix: addressing a typo * chore: pre-commit auto fixes [...] * fix: removing duplicated rows * fix: addressing review comments * fix: adding StructType hint --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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Commits on Jun 7, 2024
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feat: adding locus-breaker clumping method (opentargets#634)
* feat(schema): adding locus start/end position to the study locus schema * feat(clumping) adding clumping logic + docs * test(clumpin): adding tests for locus breaker method * test(clumping): adding semantic tests for locus breaker clumping * fix(config): reverting gwas significance threshold
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build(deps): bump wandb from 0.16.2 to 0.17.0 (opentargets#606)
Bumps [wandb](https://github.com/wandb/wandb) from 0.16.2 to 0.17.0. - [Release notes](https://github.com/wandb/wandb/releases) - [Changelog](https://github.com/wandb/wandb/blob/main/CHANGELOG.md) - [Commits](wandb/wandb@v0.16.2...v0.17.0) --- updated-dependencies: - dependency-name: wandb dependency-type: direct:production update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]>
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Commits on Jun 10, 2024
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build(deps-dev): bump ipython from 8.24.0 to 8.25.0 (opentargets#636)
Bumps [ipython](https://github.com/ipython/ipython) from 8.24.0 to 8.25.0. - [Release notes](https://github.com/ipython/ipython/releases) - [Commits](ipython/ipython@8.24.0...8.25.0) --- updated-dependencies: - dependency-name: ipython dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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Commits on Jun 11, 2024
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build(deps): bump scikit-learn from 1.4.0 to 1.5.0 (opentargets#638)
Bumps [scikit-learn](https://github.com/scikit-learn/scikit-learn) from 1.4.0 to 1.5.0. - [Release notes](https://github.com/scikit-learn/scikit-learn/releases) - [Commits](scikit-learn/scikit-learn@1.4.0...1.5.0) --- updated-dependencies: - dependency-name: scikit-learn dependency-type: direct:production update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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feat: enable interface with gcp secrets manager (opentargets#635)
* feat: enable interface with gcp secrets manager * chore: add google-cloud-secret-manager * chore: merge
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feat: credible set quality filtering (opentargets#640)
* feat: credible set quality filtering * fix: purity threshold
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Commits on Jun 13, 2024
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build(deps-dev): bump dbldatagen from 0.3.5 to 0.4.0 (opentargets#637)
Bumps [dbldatagen](https://github.com/databrickslabs/data-generator) from 0.3.5 to 0.4.0. - [Release notes](https://github.com/databrickslabs/data-generator/releases) - [Changelog](https://github.com/databrickslabs/dbldatagen/blob/master/CHANGELOG.md) - [Commits](databrickslabs/dbldatagen@release/v0.3.5...release/v0.4.0) --- updated-dependencies: - dependency-name: dbldatagen dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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feat(config): 24.06 data release fixes (opentargets#639)
* feat(config): typos fix * fix(config): moved ld_index dataset to static assets --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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Commits on Jun 14, 2024
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fix(L2GPrediction): schema validation (opentargets#642)
* feat(dataset): schema mismatch issue * feat(L2GPrediction): schema unification * fix: swapped data types --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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Commits on Jun 17, 2024
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feat(SusieFineMapperStep): add new function with boundaries (opentarg…
…ets#645) * feat(SusieFineMapperStep): add new fucntion that takes boundaries as input * fix: typo in function
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Commits on Jun 18, 2024
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refactor: delete unnecessary config files (opentargets#647)
* refactor: remove ot_pics * refactor: gwas_catalog_sumstat_preprocess config removed * refactor: ot_finngen_studies removed * refactor: ot_finngen_studies removed * refactor: window_based_clumping cleanup
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feat(ld_annotator): optional r2 threshold (opentargets#648)
* feat(ld_annotator): apply r2 threshold * feat(ld_annotator): apply r2 threshold * chore(ldannotator): change threshold to 0.5
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Commits on Jun 19, 2024
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feat(stydyLocus): adding new locus collection using boundaries (opent…
…argets#644) * feat(stydyLocus): adding new locus collection using boundaries * fix: fix in test * Update tests/gentropy/dataset/test_study_locus.py Co-authored-by: Szymon Szyszkowski <[email protected]> * chore: pre-commit auto fixes [...] --------- Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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Commits on Jun 24, 2024
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chore: enable Jupyter Notebook gateway for the Dataproc cluster (open…
…targets#651) Sometimes it is very useful to be able to spin up a Jupyter notebook on a Dataproc cluster which has access to Gentropy and all its configured environment. Previously, I already added the “enable_component_gateway” option; however, it doesn't really take any effect unless you also specify the list of components to enable, which is what I'm doing in this PR.
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feat(l2g): better l2g training, evaluation, and integration (opentarg…
…ets#576) * chore: checkpoint * chore: checkpoint * chore: deprecate spark evaluator * chore: checkpoint * chore: resolve conflicts with dev * chore: resolve conflicts with dev * chore(model): add parameters class property * feat: add module to export model to hub * refactor: make model agnostic of features list * chore: add wandb to gitignore * feat: download model from hub * chore(model): adapt predict method * feat(trainer): add hyperparameter tuning * chore: deprecate trainer tests * refactor: modularise step * feat: download model from hub by default * fix: convert omegaconfig defaults to python objects * fix: write serialised model to disk and then upload to gcs * fix(matrix): drop goldStandardSet when in predict mode * chore: pass token to access private model * chore: pass token to access private model * fix: pass right schema * chore: pre-commit auto fixes [...] * chore: fix mypy issues * build: remove xgboost * chore: merge * chore: pre-commit auto fixes [...] * chore: address comments
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Commits on Jun 25, 2024
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feat: implement UKB PPP (EUR) ingestion & harmonisation (opentargets#652
) * feat: implement UKB PPP (EUR) ingestion & harmonisation * fix: correct module name for docs * fix: definitely correct module name for docs * test: update output of neglog_pvalue_to_mantissa_and_exponent * fix: test syntax with <BLANKLINE> * Update src/gentropy/datasource/ukb_ppp_eur/summary_stats.py Co-authored-by: Szymon Szyszkowski <[email protected]> * fix: code review updates for docs and version * fix: syntax for concat_ws * style: list harmonisation steps in the docstring * style: rename freq to MAF * style: use concat_ws * style: use two distinct parameters for study index and summary stats output paths --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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chore: remove the locus_radius parameter (opentargets#659)
Code inspection shows that it is not used anymore.
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Commits on Jun 26, 2024
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chore(deps): bump python-semantic-release/python-semantic-release (op…
…entargets#656) Bumps [python-semantic-release/python-semantic-release](https://github.com/python-semantic-release/python-semantic-release) from 9.6.0 to 9.8.3. - [Release notes](https://github.com/python-semantic-release/python-semantic-release/releases) - [Changelog](https://github.com/python-semantic-release/python-semantic-release/blob/master/CHANGELOG.md) - [Commits](python-semantic-release/python-semantic-release@v9.6.0...v9.8.3) --- updated-dependencies: - dependency-name: python-semantic-release/python-semantic-release dependency-type: direct:production update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: Kirill Tsukanov <[email protected]>
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build(deps-dev): bump pydoclint from 0.4.1 to 0.5.1 (opentargets#658)
Bumps [pydoclint](https://github.com/jsh9/pydoclint) from 0.4.1 to 0.5.1. - [Release notes](https://github.com/jsh9/pydoclint/releases) - [Changelog](https://github.com/jsh9/pydoclint/blob/main/CHANGELOG.md) - [Commits](jsh9/pydoclint@0.4.1...0.5.1) --- updated-dependencies: - dependency-name: pydoclint dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: David Ochoa <[email protected]>
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Commits on Jun 28, 2024
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fix: remove check merge conflict from pre-commit (opentargets#661)
* fix: remove check merge conflict * fix: remove line for now
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Commits on Jun 30, 2024
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feat(datasets): adding new variant index model (opentargets#641)
* feat(variant annotation): new variant annotation schema + logic to extract from VEP * fix: typehints in function * refactor(variant annotation): migrating methods to the new schema * chore: pre-commit auto fixes [...] * refactor(variant index): sorting out new variant index dataset * chore: pre-commit auto fixes [...] * feature(vep): adding predictors to vep transcript object * fix(schema): fixing schema missing fields * fix(schema): fixing schema missing fields * fix(schema): fixing schema missing fields * fix(schema): fixing schema missing fields * chore: pre-commit auto fixes [...] * fix(annotation): array union under condition * fix: merging dbxref objects * feat(variants): updating variants to make more robust * feat: migrating methods to new variant index * adjusting variant index methods * some updates * rename v2g to variant to gene * chore: pre-commit auto fixes [...] * adding test * chore: pre-commit auto fixes [...] * fix(precommit): json file needed to rename to jsonl * fix(precommit): removing steps depending on old data model * fix(coftest): fixing variant index mock generation * fix: typo in package import * fix: sorting out conftest * refactor(gwas ingest): Updating GnomAD handling * refactor(gnomad): variant annotation removed, changed to variant index, steps updated * refactor: shuffling around gnomad logic * fix: references in tests * refactor: sorting out gnomad variant dag * refactor: cleaning configs and tests * docs(vep): adding datasource description * test(vep): adding more test to the vep parser * test(vep): tests are now running * fix: removing version suffix from pyproject and airflow config * fix: reverting DAGs - removing temporary modifications I added for testing * fix: addressing reviewer comments * refactor: fiddling with variant index annotation logic * chore: addressing comments * fix: variant cross-ref snake case * fix: correcting join strategy --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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Commits on Jul 3, 2024
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fix: typo in
cs_lbf_thr
parameter name (opentargets#667)* fix: typo in cs_lbf_thr parameter name * fix: removing two parameters --------- Co-authored-by: Yakov Tsepilov <[email protected]>
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fix(finemapping): link configuration and step classes (opentargets#669)
As it is, when the susie_finemapper step is triggered, nothing happens because the configuration class is not linked via _target_ to the step class. This commit addresses the problem
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Commits on Jul 4, 2024
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feat: vep annotation (dockerised + google batch + airflow) (opentarge…
…ts#608) * feat: custom dockerfile to run ensembl vep * ci: automate vep image build and artifact registry * chore: update airflow google operators (not required) * feat: working version of google batch airflow vep job * feat: working version of google batch airflow vep job * feat(VEP): adding CADD plugin * feat: local loftee file * feat: working with input bucket full of input files * feat: prevent writing html * fix: minor adjustments to retry strategy * feat(airflow): separating mounting points for input/output and cache * fix: typo in airflow dag * fix: pre-commit pain * chore: rename airflow dag file --------- Co-authored-by: DSuveges <[email protected]> Co-authored-by: Szymon Szyszkowski <[email protected]>
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Commits on Jul 8, 2024
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feat: locus_breaker_clumping (opentargets#655)
* feat: locus_breaker_clumping * fix: dosctring * feat: _process_locus_breaker function * feat: locus breaker clumping step * fix: tidying parameters * feat: option to remove MHC region * fix: description for LocusBreakerClumpingStep * fix: removing division of distance * fix: adding new parameters for wbc distance separate from large_loci_size * fix: resolving comments * refactor: refactored code in process_locus_breaker_output * fix: removing superfluous variable * fix: persisting sumstats parquet to improve analysis plan --------- Co-authored-by: Yakov <[email protected]>
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Commits on Jul 9, 2024
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feat: add qc step (opentargets#675)
* feat: add qc step * fix: remove .df * fix: fix in name * fix: fix v3 * Update src/gentropy/sumstat_qc_step.py Co-authored-by: Daniel Suveges <[email protected]> * Update src/gentropy/sumstat_qc_step.py Co-authored-by: Daniel Suveges <[email protected]> * fix: optimisation of code --------- Co-authored-by: Daniel Suveges <[email protected]>
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feat: adding sanity filter to GWASCatalogSumstatsPreprocessStep (open…
…targets#677) * feat: adding sanity filter to GWASCatalogSumstatsPreprocessStep * fix: adding description
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fix: improving locus_breaker_step logic (opentargets#679)
* fix: improving locus_breaker_step logic * fix: updating susie_finemapper.py to deal with new I/O logic * chore: removing unused log output path
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fix: reconcile changes in the finemapping step with config (opentarge…
…ts#682) Two values were recently removed from the step. This brings config in alignment with these changes.
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feat: credible set quality control step (opentargets#681)
* feat: credible set quality control step * feat: credible_set_qc.py step * chore: updating genotropy/config.py to include CredibleSetQCConfig() * chore: updated LocusBreakerClumpingConfig(StepConfig) * fix: changing default configs in code
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Commits on Jul 11, 2024
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feat(docker): image update for new orchestration (opentargets#683)
* feat: added jq to the docker image dependencies * feat: added gsutil to gentropy image * fix: added missing env vars --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat(StudyIndex): validation for study type, disease, target etc (ope…
…ntargets#672) * chore: snapshot * feat(StudyIndex): adding valiation methods * feat(studyIdex): adding disease validation * fix: typo in test * fix: moving import under the type checking condition * fix: some columns might need to be dropped * fix(study index): preventing [null] arrays in the cohorts object * fix(study index): more context is provided for disease normalisation
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build(deps-dev): bump ruff from 0.4.10 to 0.5.1 (opentargets#674)
Bumps [ruff](https://github.com/astral-sh/ruff) from 0.4.10 to 0.5.1. - [Release notes](https://github.com/astral-sh/ruff/releases) - [Changelog](https://github.com/astral-sh/ruff/blob/main/CHANGELOG.md) - [Commits](astral-sh/ruff@v0.4.10...0.5.1) --- updated-dependencies: - dependency-name: ruff dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: David Ochoa <[email protected]>
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chore: pre-commit autoupdate (opentargets#676)
* chore: pre-commit autoupdate updates: - [github.com/astral-sh/ruff-pre-commit: v0.4.3 → v0.5.1](astral-sh/ruff-pre-commit@v0.4.3...v0.5.1) - [github.com/pre-commit/mirrors-mypy: v1.10.0 → v1.10.1](pre-commit/mirrors-mypy@v1.10.0...v1.10.1) - [github.com/jsh9/pydoclint: 0.4.1 → 0.5.3](jsh9/pydoclint@0.4.1...0.5.3) * chore: update lock --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com> Co-authored-by: David Ochoa <[email protected]> Co-authored-by: David Ochoa <[email protected]>
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build(deps): bump skops from 0.9.0 to 0.10.0 (opentargets#673)
* build(deps): bump skops from 0.9.0 to 0.10.0 Bumps [skops](https://github.com/skops-dev/skops) from 0.9.0 to 0.10.0. - [Release notes](https://github.com/skops-dev/skops/releases) - [Changelog](https://github.com/skops-dev/skops/blob/main/docs/changes.rst) - [Commits](skops-dev/skops@v0.9.0...v0.10) --- updated-dependencies: - dependency-name: skops dependency-type: direct:production update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> * fix: update `trusted` in load to avoid typeerror --------- Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: Irene López <[email protected]>
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build(deps-dev): bump google-cloud-dataproc from 5.9.3 to 5.10.1 (ope…
…ntargets#684) Bumps [google-cloud-dataproc](https://github.com/googleapis/google-cloud-python) from 5.9.3 to 5.10.1. - [Release notes](https://github.com/googleapis/google-cloud-python/releases) - [Changelog](https://github.com/googleapis/google-cloud-python/blob/main/packages/google-cloud-documentai/CHANGELOG.md) - [Commits](googleapis/google-cloud-python@google-cloud-dataproc-v5.9.3...google-cloud-dataproc-v5.10.1) --- updated-dependencies: - dependency-name: google-cloud-dataproc dependency-type: direct:development update-type: version-update:semver-minor ...
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feat(variant index): calculate hash as variant id for long variants (o…
…pentargets#665) * feat(variant index): calculate hash as variant id for variants with long alleles * fix: adjusting hashing method * fix: painful iteration to get gnomad running with the new schema + fine tune with variant index * chore: fixing variant index step * fix: reverting changes * fix: minor updates * feat(variant index): null values of array columns are enforced to be replaced with empty arrays * fix: array union vs coalese fix * fix(variant index): annotation logic made more robust * fix: addressing review comments * fix: renaming helper function for better readability * fix(liftover): fixing docstring
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build(deps-dev): bump ipython from 8.25.0 to 8.26.0 (opentargets#662)
Bumps [ipython](https://github.com/ipython/ipython) from 8.25.0 to 8.26.0. - [Release notes](https://github.com/ipython/ipython/releases) - [Commits](ipython/ipython@8.25.0...8.26.0) --- updated-dependencies: - dependency-name: ipython dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: David Ochoa <[email protected]> Co-authored-by: David Ochoa <[email protected]>
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ci: prevent user from rebasing in minimal way (opentargets#691)
Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat: artifacts versionned by release (opentargets#692)
added tags to the artifact github actions triggers, so the images produced by gentropy will be versionned by tag name Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: moving hl.init (opentargets#687)
* fix: moving hl.init * fix: missed a hl.init * fix: removing the hl.init from notebooks
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chore(study_index): improve study definition for the eQTL Catalogue a…
…nd Finngen (opentargets#693) * chore: remove finngen prefix from studyIds * feat(eqtl_catalogue): changes from #3357 * fix: update study table * fix: update _identify_study_type example
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feat(studyLocus validation): adding validation logic to studyLocus da…
…taset (opentargets#686) * feat(studyLocus validation): adding validation logic to studyLocus dataset * feat: making QC more granular * Update src/gentropy/dataset/study_locus.py Co-authored-by: David Ochoa <[email protected]> --------- Co-authored-by: David Ochoa <[email protected]>
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ci: revert semantic-release update (opentargets#694)
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feat: full orchestration of the variant index dag (opentargets#678)
* feat(session): replace `read_parquet` with more general `load_data` * chore: checkpoint * feat(variant_index): overwrite variant id for longer variants * feat(variant_index): copy vcf from local filesystem to gcs * build: remove request dependency for urllib * feat(variant idx): integrate all components into dag * test: fix `fetch_coordinates` typo * Update src/airflow/dags/common_airflow.py Co-authored-by: Daniel Suveges <[email protected]> * refactor: move fetch_coordinates_from_rsids to independent module * fix: update fetch_coordinates_from_rsids example --------- Co-authored-by: Daniel Suveges <[email protected]>
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fix: fix issue with gh commit not triggering artifact workflow
Szymon Szyszkowski committedJul 15, 2024 Configuration menu - View commit details
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updates: - [github.com/astral-sh/ruff-pre-commit: v0.5.1 → v0.5.2](astral-sh/ruff-pre-commit@v0.5.1...v0.5.2) - [github.com/jsh9/pydoclint: 0.5.3 → 0.5.4](jsh9/pydoclint@0.5.3...0.5.4)
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ci: authentication with github app
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Merge pull request opentargets#698 from opentargets/il-3333-explode
fix(variants): explode loci to generate list of variants + tests
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Merge pull request opentargets#699 from opentargets/pre-commit-ci-upd…
…ate-config chore: pre-commit autoupdate
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fix(docker): change JAVA_HOME env to
/usr
Szymon Szyszkowski committedJul 16, 2024 Configuration menu - View commit details
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Co-authored-by: Irene López Santiago <[email protected]>
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Merge pull request opentargets#700 from opentargets/3384-refactoring-…
…of-the-docker-release-process-for-gentropy ci: Refactoring of the docker release process for gentropy
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Merge pull request opentargets#701 from opentargets/tskir-fix-finemap…
…ping-typo fix(finemapping): typo in "elapsed_time"
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Merge pull request opentargets#702 from opentargets/3384-allow-image-…
…push feat: allow image push
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build(deps-dev): bump pytest from 8.2.2 to 8.3.1 (opentargets#712)
Bumps [pytest](https://github.com/pytest-dev/pytest) from 8.2.2 to 8.3.1. - [Release notes](https://github.com/pytest-dev/pytest/releases) - [Changelog](https://github.com/pytest-dev/pytest/blob/main/CHANGELOG.rst) - [Commits](pytest-dev/pytest@8.2.2...8.3.1) --- updated-dependencies: - dependency-name: pytest dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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build(deps-dev): bump deptry from 0.16.1 to 0.17.0 (opentargets#714)
Bumps [deptry](https://github.com/fpgmaas/deptry) from 0.16.1 to 0.17.0. - [Release notes](https://github.com/fpgmaas/deptry/releases) - [Changelog](https://github.com/fpgmaas/deptry/blob/main/CHANGELOG.md) - [Commits](fpgmaas/deptry@0.16.1...0.17.0) --- updated-dependencies: - dependency-name: deptry dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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build(deps-dev): bump mypy from 1.10.0 to 1.11.0 (opentargets#713)
Bumps [mypy](https://github.com/python/mypy) from 1.10.0 to 1.11.0. - [Changelog](https://github.com/python/mypy/blob/master/CHANGELOG.md) - [Commits](python/mypy@v1.10.0...v1.11) --- updated-dependencies: - dependency-name: mypy dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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feat: expose summary statistics qc and locus breaker steps to hydra c…
…li (opentargets#716) * feat: expose summary statistics qc to hydra cli * feat: expose locus breaker clumping step --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: change config params to match new name (opentargets#721)
Co-authored-by: Szymon Szyszkowski <[email protected]>
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chore: pre-commit autoupdate (opentargets#715)
updates: - [github.com/astral-sh/ruff-pre-commit: v0.5.2 → v0.5.5](astral-sh/ruff-pre-commit@v0.5.2...v0.5.5) - [github.com/pre-commit/mirrors-mypy: v1.10.1 → v1.11.0](pre-commit/mirrors-mypy@v1.10.1...v1.11.0) - [github.com/jsh9/pydoclint: 0.5.4 → 0.5.6](jsh9/pydoclint@0.5.4...0.5.6) Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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build(deps-dev): bump pymdown-extensions from 10.8.1 to 10.9 (opentar…
…gets#720) Bumps [pymdown-extensions](https://github.com/facelessuser/pymdown-extensions) from 10.8.1 to 10.9. - [Release notes](https://github.com/facelessuser/pymdown-extensions/releases) - [Commits](facelessuser/pymdown-extensions@10.8.1...10.9) --- updated-dependencies: - dependency-name: pymdown-extensions dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: Szymon Szyszkowski <[email protected]>
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build(deps-dev): bump deptry from 0.17.0 to 0.18.0 (opentargets#723)
Bumps [deptry](https://github.com/fpgmaas/deptry) from 0.17.0 to 0.18.0. - [Release notes](https://github.com/fpgmaas/deptry/releases) - [Changelog](https://github.com/fpgmaas/deptry/blob/main/CHANGELOG.md) - [Commits](fpgmaas/deptry@0.17.0...0.18.0) --- updated-dependencies: - dependency-name: deptry dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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feat: notebook for locus breaker and susie finemapping benchmark (ope…
…ntargets#717) * feat: notebook for locus breaker and susie finemapping benchmark * fix: won't pass tests with matplotlib imported * feat: ukb_ppp_fm benchmark notebook * fix: check for nulls as well as nans * fix: removing matplotlib * fix: update notebooks * chore: re-run ukb ppp notebook * chore: rerun notebook
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fix: updating config paths and fine-mapping methods (opentargets#725)
* fix: updating config paths and fine-mapping methods * Update ot_locus_to_gene_train.yaml
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docs: macos fix for some functions (opentargets#729)
* docs: macos fix for some functions * docs: formatting
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build(deps-dev): bump ruff from 0.5.1 to 0.6.1 (opentargets#732)
* build(deps-dev): bump ruff from 0.5.1 to 0.6.1 Bumps [ruff](https://github.com/astral-sh/ruff) from 0.5.1 to 0.6.1. - [Release notes](https://github.com/astral-sh/ruff/releases) - [Changelog](https://github.com/astral-sh/ruff/blob/main/CHANGELOG.md) - [Commits](astral-sh/ruff@0.5.1...0.6.1) --- updated-dependencies: - dependency-name: ruff dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> * fix: linting issues associated with ruff 0.6 * chore: fixing imports for notebooks * chore: removing old notebook --------- Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: David Ochoa <[email protected]> Co-authored-by: Daniel Considine <[email protected]>
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chore: pre-commit autoupdate (opentargets#724)
* chore: pre-commit autoupdate updates: - [github.com/astral-sh/ruff-pre-commit: v0.5.5 → v0.6.1](astral-sh/ruff-pre-commit@v0.5.5...v0.6.1) - [github.com/pre-commit/mirrors-mypy: v1.11.0 → v1.11.1](pre-commit/mirrors-mypy@v1.11.0...v1.11.1) * chore: pre-commit auto fixes [...] --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com> Co-authored-by: David Ochoa <[email protected]>
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build(deps-dev): bump deptry from 0.18.0 to 0.19.1 (opentargets#728)
Bumps [deptry](https://github.com/fpgmaas/deptry) from 0.18.0 to 0.19.1. - [Release notes](https://github.com/fpgmaas/deptry/releases) - [Changelog](https://github.com/fpgmaas/deptry/blob/main/CHANGELOG.md) - [Commits](fpgmaas/deptry@0.18.0...0.19.1) --- updated-dependencies: - dependency-name: deptry dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: David Ochoa <[email protected]>
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build(deps-dev): bump lxml from 5.2.2 to 5.3.0 (opentargets#727)
Bumps [lxml](https://github.com/lxml/lxml) from 5.2.2 to 5.3.0. - [Release notes](https://github.com/lxml/lxml/releases) - [Changelog](https://github.com/lxml/lxml/blob/master/CHANGES.txt) - [Commits](lxml/lxml@lxml-5.2.2...lxml-5.3.0) --- updated-dependencies: - dependency-name: lxml dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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build(deps-dev): bump pre-commit from 3.7.1 to 3.8.0 (opentargets#719)
* build(deps-dev): bump pre-commit from 3.7.1 to 3.8.0 Bumps [pre-commit](https://github.com/pre-commit/pre-commit) from 3.7.1 to 3.8.0. - [Release notes](https://github.com/pre-commit/pre-commit/releases) - [Changelog](https://github.com/pre-commit/pre-commit/blob/main/CHANGELOG.md) - [Commits](pre-commit/pre-commit@v3.7.1...v3.8.0) --- updated-dependencies: - dependency-name: pre-commit dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> * fix: update lock --------- Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: David Ochoa <[email protected]> Co-authored-by: David Ochoa <[email protected]>
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feat(variant_index): changes for a successful run (opentargets#735)
* feat: update variant sources for variant idx and drop rsid mapping * chore: remove variant_index step from etl dag * chore: move gnomad annotation from dev to static assets * chore: change gentropy docker image * feat(convert_to_vcf): write data partitioned * feat: add vcf merging step * chore: assert merge is succesful * fix: remove non canonical variants from vcfs * chore: pass vcf types to merging rule * fix: match vep parser order of columns to variant index schema * fix: ditch `assign_variant_id` in favour of `hash_long_variant_ids` * chore: update `test_as_vcf_df_without_variant_id` * fix: correct test mock data * chore: pre-commit auto fixes [...] * chore: merge from dev * chore: pre-commit auto fixes [...] --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com> Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: update cluster creation command (opentargets#739)
Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: revert recursiveFileLookup to False (opentargets#738)
Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat: Finngen r11 ingestion (opentargets#733)
* feat: finngen r11 study index paths * feat: simplification of finngen susie finemapping ingestion * feat: efos in finngne study index * docs: updated docstring * fix: pass spark_session not gentropy session to step * fix: read uploaded file requires file:/// * fix: parallelize csv from url * fix: typo in docstring * chore: pre-commit auto fixes [...] --------- Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com> Co-authored-by: Daniel Suveges <[email protected]>
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fix: adding carma_tau parameter to susie_finemapper (opentargets#743)
* fix: adding carma_tau parameter to susie_finemapper * fix: changing default * fix: defaults
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feat: logic and airflow pipeline for validation (opentargets#730)
* refactor: generalised validation logic * refactor: generalised validation logic * fix(airflow): fine-tuning DAG for data validation * fix(validation): study locus uniqueness fixed * feat: add invalid/valid dataset generation in validation steps/dag (opentargets#734) * fix: does not belong in this PR * refactor: to be moved to orchestration repo * docs: respective docs pages for the steps * docs: ammend docstrings * revert: maintain dag for now but it should be removed eventually * feat: validate study_locus dataset to produce valid or invalid df * feat: adjust DAG to parametrise dataset validation * fix: duplicated row * feat: increase abstraction of Dataset validation of rows * docs: increase clarity of what the function does * fix: error message * revert: unintended change * test: testing dataset filtering by quality flag --------- Co-authored-by: DSuveges <[email protected]> * chore: pre-commit auto fixes [...] --------- Co-authored-by: David Ochoa <[email protected]> Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com> Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat(variant index): improved data structure (opentargets#710)
* feat(variant index): upating schema and logic * feat(variant index): vep transcript annotation improved with consequence score + transcript index * refactor: removed hardcoded schema definition from parser * fix(test): fixing mock variant index * fix: schema extraction fixed * fix: doctest issue resolved * fix: updating vep command in the DAG * fix: removing un-used sequence ontology terms * fix: adding example to sorter method + changing variable names --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix(finngen_r11): preserve all studyIds (opentargets#747)
* fix(finngen_r11): preserve all studyIds Preserve all studyIds, even if EFO mapping is missing, so mapping between studyIndex and StudyLocus is by studyId column is accurate. * fix: typo in docstring Co-authored-by: Irene López Santiago <[email protected]> --------- Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: Irene López Santiago <[email protected]>
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feat: adding finemapping method to studylocusid hash (opentargets#744)
* feat: adding finemapping method to studylocusid hash * chore: updating function in needed files * test: update doc test * fix: mistakes * fix: tidying logic * chore: adding studyLocusId recalculation to pics finemapping method --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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build(deps-dev): bump ipython from 8.26.0 to 8.27.0 (opentargets#741)
Bumps [ipython](https://github.com/ipython/ipython) from 8.26.0 to 8.27.0. - [Release notes](https://github.com/ipython/ipython/releases) - [Commits](ipython/ipython@8.26.0...8.27.0) --- updated-dependencies: - dependency-name: ipython dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: Szymon Szyszkowski <[email protected]>
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build(deps-dev): bump deptry from 0.19.1 to 0.20.0 (opentargets#742)
Bumps [deptry](https://github.com/fpgmaas/deptry) from 0.19.1 to 0.20.0. - [Release notes](https://github.com/fpgmaas/deptry/releases) - [Changelog](https://github.com/fpgmaas/deptry/blob/main/CHANGELOG.md) - [Commits](fpgmaas/deptry@0.19.1...0.20.0) --- updated-dependencies: - dependency-name: deptry dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: validation name mapping (opentargets#753)
* fix: use mapping instead of enum values in valid_rows * fix: typos * fix: swap valid and invalid paths --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: removing old functions (opentargets#752)
Co-authored-by: Szymon Szyszkowski <[email protected]>
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refactor: generalise per-chromosome processing (opentargets#754)
* refactor: move VA preparation logic into a separate module * refactor: generalise per-chromosome summary stats ingestion * Update src/gentropy/common/per_chromosome.py Co-authored-by: Szymon Szyszkowski <[email protected]> --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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refactor: generalise the harmonisation pipeline (opentargets#755)
* refactor: move harmonisation into a separate module * refactor: make column names configurable * feat: make INFO and A1FREQ columns optional * docs: expand comments on tmp_variant_annotation_path and variant types
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feat: ingest FinnGen UKB meta-analysis data (opentargets#756)
* feat: implement FinnGen UKB meta-analysis ingestion and harmonisation * chore: remove ot_finngen_ukb_meta.yaml * chore: remove raw_study_index_path to raw_study_index_path_from_tsv * fix: use session.write_mode * style: rename class to FinngenUkbMetaIngestionStep
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feat(validation): adding credible set variant validation (opentargets…
…#757) * feat(validation): adding logic to validate credible sets against variant index * fix: tidying docstrings
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feat: drop airflow orchestration layer from gentropy (opentargets#758)
* refactor: drop gentropy config * feat(airflow): removal of airflow orchestration BREAKING CHANGE: see https://github.com/opentargets/orchestration --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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Commits on Sep 13, 2024
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build(deps): bump wandb from 0.17.2 to 0.18.0 (opentargets#763)
Bumps [wandb](https://github.com/wandb/wandb) from 0.17.2 to 0.18.0. - [Release notes](https://github.com/wandb/wandb/releases) - [Changelog](https://github.com/wandb/wandb/blob/main/CHANGELOG.md) - [Commits](wandb/wandb@v0.17.2...v0.18.0) --- updated-dependencies: - dependency-name: wandb dependency-type: direct:production update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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fix: prevent multiple credible filters to override spark plan (openta…
…rgets#766) * fix: prevent multiple filters to override spark plan * feat: mhc quality control flag * fix: prevent multiple filters to override spark plan * Revert "fix: prevent multiple filters to override spark plan" This reverts commit a358781. * revert: wrong commit * fix: missing changes due to git chaos * chore: merge dev toml, update lock * chore: update lock after upgrading poetry to 1.8.3 v 2 --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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Commits on Sep 18, 2024
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feat: flag MHC credible sets based on lead (opentargets#767)
* fix: prevent multiple filters to override spark plan * feat: mhc quality control flag * fix: typo * docs: genomic region added to docs * docs: info added to common index (and title) * docs: fix paths * Update src/gentropy/study_locus_validation.py * fix: remove unnecessary comment --------- Closes opentargets/issues#3469 Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix(effect harmonisation): addressing beta harmonisation bug (opentar…
…gets#762) * fix: turning OR to beta harmonisation on for GWAS Catalog * fix(ingestion): addressing beta harmonisation bug * fix(ingestion): addressing beta harmonisation bug * test: adding test for effect harmonisation * test: adding doctests for beta harmonisation * fix: fixing value checking bug: effect value needs to be cast to double type * fix: typos in gwas ingestion script
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perf: quickly build a Docker image for every branch (opentargets#773)
* perf: cache Docker image layers * chore: temporary add branch to test * perf: separate AMD and ARM builds for gentropy * perf: temporarily test only VEP image separately * perf: test ARM/AMD gentropy/VEP separately * perf: introduce quick build for all commits * perf: quick build for all tags * fix: use correct syntax for tags * fix: revert accidental changes for the VEP step
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docs: fix broken refs (opentargets#768)
Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat: flag PICS top hits in studies with credset sumstats (opentarget…
…s#777) Co-authored-by: Daniel Suveges <[email protected]>
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fix(ld clumping): a revised logic allows a more accurate clumping (op…
…entargets#772) * fix(ld clumping): a revised logic allows a more accurate identification of linked loci * test: adding some test * chore: pre-commit auto fixes [...] * test: adding more test cases * fix: fixing test data --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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refactor(L2GFeatureMatrix)!: streamline feature matrix management (op…
…entargets#745) * refactor(L2GFeatureMatrix): remove schema validation * refactor(FeatureFactory): reshape feature generation WIP * chore: pre-commit auto fixes [...] * chore: set l2gfeature properties with decorator * chore(l2gfeature): make credible_set and input_dependency instance attributes * chore(l2gfeature): make credible_set and input_dependency instance attributes * chore(featurefactory): distanceTssMeanFeature working * refactor(l2g): improve step dependency management * feat: implement * chore: fix mypy issues * feat: l2gfeaturematrix.from_features_list working * chore: comment out obsolete refs * chore(L2GFeatureMatrix): change `mode` attribute to `with_gold_standard` * refactor(l2g): move feature matrix writing to training module * feat(L2GFeatureMatrix): accept L2GGoldStandard or StudyLocus as inputs * feat: implement methods to build a feature matrix based on a studylocus/L2GGoldStandard instance * feat: coloc logic prototype * feat(l2g): filter non gwas credible sets at the start of the step * feat: rewrite colocalisation feature factory * test: add `test_colocalisation_feature_type` * test(colocalisation): add test_extract_maximum_coloc_probability_per_region_and_gene * feat(L2GFeatureInputLoader): support multiple deps by passing loader as kwarg * test: add integration tests `test_build_feature_matrix` * chore: drop config yamls * refactor: move feature classes to datasets module * docs: update feature docs * refactor(colocalisation): cleaner joins in `append_right_study_metadata` * chore: better logging abstract methods * test: add `L2GFeatureMatrix.test_from_features_list` unit tests * fix: add goldStandardSet when a gs instance is passed to `from_features_list` * fix: lowercase colocalisation type and add semantic test * test: add semantic test for `append_right_study_metadata` * feat(colocalisation): make `append_right_study_metadata` extensible to left metadata * fix(colocalisation): append_study_metadata cant take a gold standard * fix(colocalisation): extract_maximum_coloc_probability_per_region_and_gene cant take a gold standard * feat: add `StudyLocus` as a dependency of colocalisation features * fix: add studylocus to input loader in test * fix: add studylocus to input loader in test * fix: add studylocus to input loader in test
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Commits on Sep 24, 2024
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feat: add
studyType
toStudyLocus
andColocalisation
(and `Stud……yLocusOverlap`) (opentargets#782) * feat: add studyType to StudyLocus schema * feat: add annotate_study_type function to add studyType to StudyLocus * fix: remove lines for retrieving studyType as StudyLocus now contains studyType * fix: add studyType to test input data as StudyLocus now contains studyType * feat: add leftStudyType and rightStudyType to Colocalisation and StudyLocusOverlap schemas * feat: update _convert_to_square_matrix and its test with leftStudyType and rightStudyType * feat: update test_find_overlaps_semantic inputs with leftStudyType and rightStudyType * feat: update tests in test_colocalisation_method.py with leftStudyType and rightStudyType * feat: add leftStudyType and rightStudyType when creating StudyLocusOverlap * feat: add leftStudyType and rightStudyType to Colocalisation results * fix: remove redundant study_index parameter from filter_by_study_type function def and calls * fix: remove redundant study_index parameter from find_overlaps function def and calls * fix: remove leftStudyType from Colocalisation (not needed as always gwas) * fix: remove leftStudyType from StudyLocusOverlap (not needed as always gwas) * fix: missing comma * feat: update tests in test_locus_to_gene.py with studyType and rightStudyType * feat: update tests (colocalisation, l2g, l2g feature matrix) with rightStudyType * fix: remove studyType from metadata_cols in append_study_metadata function call
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feat: adding window based clumping to StudyLocus (opentargets#779)
* feat: adding window based clumping to locus * fix: reverting some changes * chore: pre-commit auto fixes [...] * fix: fixing probem introduced by merge conflict * fix: addressing review comment --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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feat: add biosample index (opentargets#769)
* Initial commit of biosample index * Make minimal class * Tidy up first draft of adding biosample index * Add beginning of logic for checking if biosample from a studyindex is in biosample index * Make early file for merging multiple biosample indices into one * Finish adding basic iteration of biosample index, needs debugging * Tweak slightly * Modified the parser to accept JSON files * Update biosample index * Tests and docs * Updating tests * Revert GWAS catalog file * fix(biosample index): update to match pre-commit standards * fix(biosample index): merging indices fix * fix(biosample index): update study index qc logic * fix(biosample index): fix missing mock_biosample_index * chore(biosample index): change datasource name from ontologies * fix(biosample index): add dataset doc * fix(biosample index): change dbXrefs to xrefs * chore (biosample index): better commenting Co-authored-by: Daniel Suveges <[email protected]> * fix(biosample index): various minor tweaks to biosample index * fix(biosample index): minor bug * fix(biosample index): fix merge shift to method * feat(biosample index): make biosampleName not nullable --------- Co-authored-by: Daniel Suveges <[email protected]>
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feat: 99% credible set validation during
study_locus_validation
(op……entargets#765) * feat: study locus validation filters for 95% credible sets * revert: no longer needed to filter for credible set interval * feat: annotate credible sets before filter them * docs: adding more context here
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feat: flag credible sets explained by SuSiE regions (opentargets#780)
* feat: flag PICS top hits in studies with credset sumstats * feat: flag credible sets explained by SuSiE region * feat: consider unresolved LD cases * refactor: improve readability of code * refactor: improve code readability --------- Co-authored-by: Daniel Suveges <[email protected]>
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build(deps-dev): bump pymdown-extensions from 10.9 to 10.10.1 (openta…
…rgets#781) Bumps [pymdown-extensions](https://github.com/facelessuser/pymdown-extensions) from 10.9 to 10.10.1. - [Release notes](https://github.com/facelessuser/pymdown-extensions/releases) - [Commits](facelessuser/pymdown-extensions@10.9...10.10.1) --- updated-dependencies: - dependency-name: pymdown-extensions dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: David Ochoa <[email protected]>
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fix(finngen_study_index): improved tests for finngen study index (ope…
…ntargets#776) * fix(finngen_study_index): improved tests for finngen study index * chore(tests): added pytest mark to be able to isolate step tests * chore: pr comments * feat: revert mock.patch --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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Commits on Sep 25, 2024
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fix(safe_array_union): allow for sorting nested structs (opentargets#793
) * fix: remove study_index_path from coloc step * fix(safe_array_union): sort struct fields in array --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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Commits on Sep 30, 2024
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fix(schema): recursive validation of arbitrarily deep nested structure (
opentargets#790) * fix(schema): recursive validation of arbitrariliy deep nested structure * chore: pre-commit auto fixes [...] * fix: docstring issues * fix: failing tests are fixed * test: skipping tests that are failing because bug in vep parser * test(schemas): adding tests for schema comparison functions * test: removing skip as the vep parser logic is fixed * fix: addressing review comments * fix(schemas): removing schema flattening function * chore: pre-commit auto fixes [...] --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com> Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: adding data specific p-value filters (opentargets#788)
* fix: adding data specific fillters * fix: removing variables * fix: adding options to init --------- Co-authored-by: Daniel Suveges <[email protected]>
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feat: change
StudyLocusId
hashing method to md5 (and change `StudyL……ocusId` to string type) (opentargets#783) * feat: change studyLocusId to string in schema * feat: change studyLocusId of example data to string in tests * feat: change hashing method to md5 * test: remove test_assign_study_locus_id__null_variant_id as validation will have removed null ids * fix: change studyLocusId to string in remaining files * fix: ensure inputs to assign_study_locus_id are columns and not strings * fix: change studyLocusId to string in remaining files * chore: update assign_study_locus_id docstring with updated output * chore: update assign_study_locus_id docstring with updated output (again) * fix: change studyLocusId to string in recently merged files * feat: move hashing logic to generate_identifier function in Dataset class --------- Co-authored-by: Daniel Suveges <[email protected]>
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feat: drop
v2g
and reimplement distance features (opentargets#771)* refactor(L2GFeatureMatrix): remove schema validation * refactor(FeatureFactory): reshape feature generation WIP * chore: pre-commit auto fixes [...] * chore: set l2gfeature properties with decorator * chore(l2gfeature): make credible_set and input_dependency instance attributes * chore(l2gfeature): make credible_set and input_dependency instance attributes * chore(featurefactory): distanceTssMeanFeature working * refactor(l2g): improve step dependency management * feat: implement * chore: fix mypy issues * feat: l2gfeaturematrix.from_features_list working * chore: comment out obsolete refs * chore(L2GFeatureMatrix): change `mode` attribute to `with_gold_standard` * refactor(l2g): move feature matrix writing to training module * feat(L2GFeatureMatrix): accept L2GGoldStandard or StudyLocus as inputs * feat: implement methods to build a feature matrix based on a studylocus/L2GGoldStandard instance * feat: coloc logic prototype * feat(l2g): filter non gwas credible sets at the start of the step * feat: rewrite colocalisation feature factory * test: add `test_colocalisation_feature_type` * test(colocalisation): add test_extract_maximum_coloc_probability_per_region_and_gene * feat(L2GFeatureInputLoader): support multiple deps by passing loader as kwarg * test: add integration tests `test_build_feature_matrix` * feat(variant_index): add `get_distance_to_gene` and deprecate `get_distance_from_tss` * feat(variant_index): deprecate `get_most_severe_transcript_consequence` * feat(variant_index): add `get_loftee` and deprecate `get_plof_v2g` * chore: reduce v2g assesments to intervals * feat(feature_factory): add distance to footprint features * test: refactor `test_feature_factory_return_type` * feat(feature_factory): add all distance neighbourhood features * chore: delete v2g * feat(feature_factory): add all colocalisation neighbourhood features * chore: final v2g deletion * chore: drop config yamls * refactor: move feature classes to datasets module * docs: update feature docs * fix: import * test: add semantic `TestCommonColocalisationFeatureLogic` * test: add semantic `TestCommonDistanceFeatureLogic` * refactor: separate features into diff modules * fix: documentation references * feat: implement distance to sentinel and adapt definitions * docs: update distance class names * fix: add all variant index mandatory fields in tests * fix(schema_validator): remove extra `[]` from parent prefix * fix: convert studylocusid to string in tests * revert: revert 72ea515 (it was ok) * fix: adapt test
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feat: out sample LD qc reason (opentargets#798)
Co-authored-by: Daniel Suveges <[email protected]>
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chore: drop redundant parameter (opentargets#802)
Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: align the schema of study_index for ukb ppp eur (opentargets#803)
* fix(ukb_ppp_study_index): update column name to match schema * chore: add note that notebooks are not supported --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat: force reinstallation of the gentropy on the cluster (opentarget…
…s#804) Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat(validation): adding credible set confidence annotation at valida…
…tion time (opentargets#801) * feat: adding credible set confidence * feat: adding confidence assignment to the credible set validation step * fix: adding confidence field to schema * fix: schema * fix: confidence criteria * fix: finalising labels * fix: docstring typo * test: for credible set confidence assignment
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chore: make the lb clumping ingest the partitionned data (opentargets…
…#806) Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat: adding filtering to susie finemapper (opentargets#796)
* feat: adding filltering to susie fine_mapper * fix: correct options * fix: fix simulations * fix: correct clumping * fix: fix options * fix: fix for catching None * fix: adding LD and gwas_df as output * chore: changing defaults * chore: v1 * fix: spelling in susie_finemapper.py --------- Co-authored-by: Daniel-Considine <[email protected]>
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feat: add sumstat QC fields to schema (opentargets#809)
* feat: add sumstat QC fields to schema * fix: fix of type * fix: fix for struct
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feat: fix biosample study validation (opentargets#810)
* fix(biosample index): update biosample index validation step to only apply to non-gwas studies * fix(biosample index): revert to dropping * feat(biosample index): update test study index to test biosample index too * feat(biosample index): add biosampleId to study index schema
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refactor(vep_parser): store consequence to impact score as a project …
…config (opentargets#811) * refactor: set variant functional consequence to pathogenicity score as class attribute * chore: drop `VariantIndex.get_most_severe_gene_consequence` * chore(VariantIndex): make `CONSEQUENCE_TO_PATHOGENICITY_SCORE` a class attribute * fix(vep): convert `id_to_score_map` to `label_to_score_map` * chore: remove comment * refactor: move `consequence_to_pathogenicity_score` to `VariantIndexConfig`
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feat(l2g): implement variant consequence features from VEP (opentarge…
…ts#805) * feat(variant_index): set variant functional consequence to pathogenicity score as class attribute * feat: add and test vep features * feat: add and test vep neighbourhood features * feat(vep_features): use only protein coding genes to look in the vicinity * chore: update feature list and other bits * fix: docs ref * refactor: set variant functional consequence to pathogenicity score as class attribute * chore: drop `VariantIndex.get_most_severe_gene_consequence` * chore(VariantIndex): make `CONSEQUENCE_TO_PATHOGENICITY_SCORE` a class attribute * fix(vep): convert `id_to_score_map` to `label_to_score_map` * chore: remove comment * chore: access max consequence score from variant index
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feat: optimisation of qc step (opentargets#813)
* feat: optimisation of qc step * fix: adding Z2 filter * fix: v1
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fix(validation): add
qualityControls
column if missing in StudyLocu……s dataset when perfroming validation (opentargets#814) * fix: coalesce qualityControl column in credible set * fix: resolve missing qualityControls column when validating studyLocus * chore: whitespace * chore: use getter to infer qc column name * chore: drop show * chore: drop warnings for step_test(s) --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: fix of type error in schema checking (opentargets#817)
* fix: fix of type error in schma checking * fix: fix fix fix
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fix: biosample id duplication (opentargets#822)
* fix(biosample_index): remove biosampleId column if present in validation and tests * fix(biosample index): update tests for biosample index
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feat: change LD annotation for PICS fine-mapping to use major ancestry (
opentargets#821) * feat: add functions to get the major population and calculate r2 * refactor: remove functions not needed anymore * refactor: change r2Overall to r2Major * test: add tests for both of the added functions * test: remove tests no longer needed * revert: change r2Major back to r2Overall
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build(deps-dev): bump ipython from 8.27.0 to 8.28.0 (opentargets#819)
Bumps [ipython](https://github.com/ipython/ipython) from 8.27.0 to 8.28.0. - [Release notes](https://github.com/ipython/ipython/releases) - [Commits](ipython/ipython@8.27.0...8.28.0) --- updated-dependencies: - dependency-name: ipython dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: Szymon Szyszkowski <[email protected]>
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build(deps-dev): bump pre-commit from 3.8.0 to 4.0.0 (opentargets#820)
Bumps [pre-commit](https://github.com/pre-commit/pre-commit) from 3.8.0 to 4.0.0. - [Release notes](https://github.com/pre-commit/pre-commit/releases) - [Changelog](https://github.com/pre-commit/pre-commit/blob/main/CHANGELOG.md) - [Commits](pre-commit/pre-commit@v3.8.0...v4.0.0) --- updated-dependencies: - dependency-name: pre-commit dependency-type: direct:development update-type: version-update:semver-major ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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feat: decouple feature generation from L2G training step (opentargets…
…#823) * fix: join between gold standard and credible set based on studyId and variantId * fix: minor bugs to generate the feature matrix * fix(colocalisation): safeguard existing rightStudyType when applying `append_study_metadata` * feat: add feature generation step (working interactively) * feat(l2g): remove feature generation from `LocusToGeneStep` * fix: correct feature names * feat: filter gwas credible sets in `L2GPrediction.from_credible_set` * chore: update docs * chore: pass credible set to `L2GGoldStandard.build_feature_matrix` in test * chore: uncomment code
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revert: no longer rescuing variants not in LD matrix when overlapping…
… with SuSiE (opentargets#827) * revert: no longer rescueing variants not in LD matrix * test: update test to cover new expectation
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fix: empty inSilicoPredictors object in GnomAD variant index (opentar…
…gets#807) * fix: empty inSilicoPredictors object in variant index * fix: object filtering expression * fix(hail): limit removed
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feat(l2g): merge sQTL and tuQTL colocalisation features (opentargets#824
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fix: adding single point statistics to pics loci (opentargets#832)
* fix: adding single point statistics to pics loci * fix: patching field update logic * refactor: simplifying the pics process slightly * test: for lead statistics propagation * refactor: udf as decorator * fix: removing commented rows * fix: reverting udf decorator - tests would fail otherwise
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fix(find_overlap): missing right study type in output (opentargets#828)
* fix: rightStudyType nulls removed * test: improve testing of peak overlap function * fix: overlap test --------- Co-authored-by: David Ochoa <[email protected]>
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Commits on Oct 12, 2024
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feat: adding new LD interface (opentargets#759)
* feat: adding new LD interface * fix: adding ld_index * fix: adding csa * fix: adding fucntion in init * chore: temporary commit to build the Docker image * chore: revert temporary GitHub Actions configuration * chore: committing some restructuring * chore: committing some changes * chore: tweaking variable names * fix: fixing locus index boundaries * docs: documenting where gnomad ht were sourced from * fix: adding afr ancestry to panUKBB interface * fix: fixing arguments for susie_finemapper * fix: removing unneeded code from panukbb ld * feat: ancestry mapping * fix: remove chr from chromosome column + some other bugs * fix: removing duplicated variants & resolving flipped indels * chore: committing changes * Update src/gentropy/datasource/pan_ukbb_ld/ld.py Co-authored-by: Daniel Suveges <[email protected]> * Update src/gentropy/method/ld_matrix_interface.py Co-authored-by: Daniel Suveges <[email protected]> * Update colocalisation.py * fix: rightStudyType nulls removed * test: improve testing of peak overlap function * fix: overlap test * fix: changes suggested by ds review * chore: removing unneeded variants.py --------- Co-authored-by: Kirill Tsukanov <[email protected]> Co-authored-by: Daniel Considine <[email protected]> Co-authored-by: Daniel-Considine <[email protected]> Co-authored-by: Daniel Suveges <[email protected]>
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fix(l2g): remove custom session params + other fixes (opentargets#841)
* chore: delete l2g custom spark session * fix: add neighbourhood features in `LocusToGeneFeatureMatrixConfig` * fix(feature_matrix): use right config for default values
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build(deps-dev): bump pymdown-extensions from 10.10.1 to 10.11.2 (ope…
…ntargets#815) Bumps [pymdown-extensions](https://github.com/facelessuser/pymdown-extensions) from 10.10.1 to 10.11.2. - [Release notes](https://github.com/facelessuser/pymdown-extensions/releases) - [Commits](facelessuser/pymdown-extensions@10.10.1...10.11.2) --- updated-dependencies: - dependency-name: pymdown-extensions dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com> Co-authored-by: Irene López Santiago <[email protected]>
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build(deps-dev): bump mkdocs-git-committers-plugin-2 from 2.3.0 to 2.…
…4.1 (opentargets#818) Bumps [mkdocs-git-committers-plugin-2](https://github.com/ojacques/mkdocs-git-committers-plugin-2) from 2.3.0 to 2.4.1. - [Release notes](https://github.com/ojacques/mkdocs-git-committers-plugin-2/releases) - [Commits](ojacques/mkdocs-git-committers-plugin-2@2.3.0...2.4.1) --- updated-dependencies: - dependency-name: mkdocs-git-committers-plugin-2 dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]>
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build(deps-dev): bump pyparsing from 3.1.2 to 3.2.0 (opentargets#836)
Bumps [pyparsing](https://github.com/pyparsing/pyparsing) from 3.1.2 to 3.2.0. - [Release notes](https://github.com/pyparsing/pyparsing/releases) - [Changelog](https://github.com/pyparsing/pyparsing/blob/master/CHANGES) - [Commits](pyparsing/pyparsing@pyparsing_3.1.2...3.2.0) --- updated-dependencies: - dependency-name: pyparsing dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]>
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build(deps-dev): bump mkdocstrings-python from 1.11.1 to 1.12.1 (open…
…targets#842) Bumps [mkdocstrings-python](https://github.com/mkdocstrings/python) from 1.11.1 to 1.12.1. - [Release notes](https://github.com/mkdocstrings/python/releases) - [Changelog](https://github.com/mkdocstrings/python/blob/main/CHANGELOG.md) - [Commits](mkdocstrings/python@1.11.1...1.12.1) --- updated-dependencies: - dependency-name: mkdocstrings-python dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]>
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chore: adding priors to coloc step (opentargets#830)
* chore: adding priors to step * fix: making specifying the priors optional * fix: revert optional --------- Co-authored-by: Daniel Considine <[email protected]> Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: fix ukbppp studindex (opentargets#839)
* fix: fix ukbppp studindex * fix: review --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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fix: l2g fixes (opentargets#844)
* fix: unnecessary session object * fix: circular dependency * revert: broadcast * fix: join * feat(l2g): persist feature matrix in l2g training plan (opentargets#843) * fix(gold_standard): remove extra columns in `build_feature_matrix` * fix: uncomment filter overlaps * feat(feature_matrix): `select_features` returns a new instance * fix(overlaps): add missing columns in `_convert_to_square_matrix` * fix(l2g): set `variant_index_path` as optional in step config * fix(l2g): set `feature_matrix_path` as mandatory in step config * fix(l2g): set `predictions_path` as optional in step config * chore(feature_matrix): remove `features_list` default from step * chore: fix `test_filter_unique_associations` toy data * chore: fix `test_filter_unique_associations` toy data --------- Co-authored-by: Irene López Santiago <[email protected]> Co-authored-by: Irene López <[email protected]>
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chore: remove h4/h3 ratio (opentargets#829)
* chore: remove h3/h4 ratiob * fix: remove it from schema * fix: conftest * fix: h3h4
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fix: updating the susie_finemapper init (opentargets#846)
* fix: updating the susie_finemapper init * fix: more fixes * fix: v2 * fix: v2 --------- Co-authored-by: Yakov Tsepilov <[email protected]>
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feat(coloc): step refactoring (opentargets#845)
* feat: prior fix * refactor: coloc step * fix: subclasss colocalisation methods on interface * fix: failing coloc step * chore(coloc): step tests * chore: restore old script --------- Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: project-defiant <[email protected]>
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fix(eqtl): deduplicating credible set loci (opentargets#849)
* fix(eqtl): deduplicating credible set loci * fix: removing
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chore: adding logging even when no CS in locus (opentargets#848)
* chore: adding logging even when no CS in locus * fix: addin CS count to log
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feat(l2g): limit colocalisation neighbourhood to protein coding genes (…
…opentargets#847) * feat(l2g): wip - limit colocalisation neighbourhood to protein coding genes * feat: adjust logic in `common_neighbourhood_colocalisation_feature_logic` * fix: correct logic in `common_neighbourhood_vep_feature_logic` * chore: adjust tests
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fix: filter nan in CSs (opentargets#855)
* fix: filter nan in CSs * fix: fix v1
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feat(susie_finemapper): allow for extraction of the log file from man…
…ifest (opentargets#859) * feat(susie_finemapper): allow for extraction of the log file from manifest * fix: add missing extension to the log file * fix: row istead of column --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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chore(coloc): changing the content of
numberColocalisingVariants
fi……eld (opentargets#857) * chore(coloc): chaning the content of numberColocalisingVariants * chore: pre-commit auto fixes [...] * fix: adjuting for schema and tests * fix(pics): ensuring locus has variantId * fix: pics udf test * fix: udf keys --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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fix: adding beta for lead variant (opentargets#863)
* fix: adding beta for lead variant * fix: v1
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fix: biosample index add efo cell types (opentargets#853)
* feat(biosample_index_add_efo): update regex to allow removal of multiple biosample id url prefixes * feat(biosample_index_add_efo): add a dummy dataset for efo biosample id, created by copy-pasting nodes and edges from full json * feat(biosample_index_add_efo): add efo (cell info) to biosample index * feat(biosample_index_add_efo): add biosample index efo tests * chore: pre-commit auto fixes [...] * chore: remove redundant tests --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com> Co-authored-by: Daniel Suveges <[email protected]>
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feat(l2g): extend colocalisation neighbourhood metrics to missing gen…
…es in the vicinity (opentargets#851) * feat(l2g): wip - limit colocalisation neighbourhood to protein coding genes * feat: adjust logic in `common_neighbourhood_colocalisation_feature_logic` * fix: correct logic in `common_neighbourhood_vep_feature_logic` * chore: adjust tests * chore: wip * feat: add `extend_missing_colocalisation_to_neighbourhood_genes` * feat: add variant index as a dependency to the colocalisation nbh features * test: add `test_extend_missing_colocalisation_to_neighbourhood_genes` * chore: minor * chore: fixes tests
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fix: add scQTLs into coloc features (opentargets#833)
* fix: add scQTLs into coloc features * fix: include single cell qtls in the list of valid study types --------- Co-authored-by: Irene López <[email protected]>
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chore: pre-commit autoupdate (opentargets#866)
updates: - [github.com/astral-sh/ruff-pre-commit: v0.6.7 → v0.7.0](astral-sh/ruff-pre-commit@v0.6.7...v0.7.0) - [github.com/pre-commit/pre-commit-hooks: v4.6.0 → v5.0.0](pre-commit/pre-commit-hooks@v4.6.0...v5.0.0) - [github.com/pre-commit/mirrors-mypy: v1.11.2 → v1.12.1](pre-commit/mirrors-mypy@v1.11.2...v1.12.1) - [github.com/jsh9/pydoclint: 0.5.8 → 0.5.9](jsh9/pydoclint@0.5.8...0.5.9) Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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feat: gwas catalog top-hit + study step (opentargets#808)
* fix: wrong step parameter * fix: persist va_subset * fix: remove broadcasts * feat: new gwas_catalog_top_hits step * docs: new step added to documentation * fix: incorrect target * fix: failing tests * fix: extra argument * fix: select does not require hasSumstats anymore * feat: study inclusion step repurposed into study index step * docs: fix path for documentation * feat: remove GWASCatalogIngestionStep as it will no longer be necessary * fix: gwas catalog study curation step * refactor: rename step * perf: repartition study locus before PICS to gain parallellisation * fix: incorrect partitioning * revert: partitioning * fix: drop duplicate rows after ingesting associations * fix: fix in study index ingestion * fix: v1 * feat: working study index with sumstats qc and curation * test: deprecate obsoleted testt * test: remove colon causing tests to fail * test: curation quality controls no longer * fix: changing mapping for ancestries adding CSA * fix: revert changes in mapping --------- Co-authored-by: Daniel Suveges <[email protected]> Co-authored-by: Vivien Ho <[email protected]> Co-authored-by: Yakov <[email protected]> Co-authored-by: Szymon Szyszkowski <[email protected]>
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build(deps-dev): bump mypy from 1.11.0 to 1.12.1 (opentargets#865)
Bumps [mypy](https://github.com/python/mypy) from 1.11.0 to 1.12.1. - [Changelog](https://github.com/python/mypy/blob/master/CHANGELOG.md) - [Commits](python/mypy@v1.11...v1.12.1) --- updated-dependencies: - dependency-name: mypy dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]>
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feat: adding desision tree to fine-mapper (opentargets#860)
* feat: adding dession tree to fine-mapper * fix: adding the rest * fix: v1 * fix: v3 * fix: v3 * fix: v5 * fix: v6 * fix: v7 * fix: change flags * fix: keys --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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build(deps-dev): bump ruff from 0.6.1 to 0.7.0 (opentargets#864)
Bumps [ruff](https://github.com/astral-sh/ruff) from 0.6.1 to 0.7.0. - [Release notes](https://github.com/astral-sh/ruff/releases) - [Changelog](https://github.com/astral-sh/ruff/blob/main/CHANGELOG.md) - [Commits](astral-sh/ruff@0.6.1...0.7.0) --- updated-dependencies: - dependency-name: ruff dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]>
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Commits on Oct 23, 2024
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chore: add chromosome validation (opentargets#869)
* chore: add chromosome validation * test: chromosome validation --------- Co-authored-by: DSuveges <[email protected]>
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feat: add gene count features to l2g (opentargets#852)
* feat: add gene count features to l2g * fix: add genecount to pytest * fix: use alias in gene count * fix: use alias in gene count * fix: pytest now works * chore: pre-commit auto fixes [...] * fix: type hint * feat(coloc): step refactoring (opentargets#845) * feat: prior fix * refactor: coloc step * fix: subclasss colocalisation methods on interface * fix: failing coloc step * chore(coloc): step tests * chore: restore old script --------- Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: project-defiant <[email protected]> * test: skip `fetch_coordinates_from_rsids` (opentargets#850) * fix(eqtl): deduplicating credible set loci (opentargets#849) * fix(eqtl): deduplicating credible set loci * fix: removing * chore: adding logging even when no CS in locus (opentargets#848) * chore: adding logging even when no CS in locus * fix: addin CS count to log * fix: type hints * added test_l2g_feature tests * fix: remove print statements from tests * feat: add genecount features to FM + config * feat: add to l2g config * chore: pre-commit auto fixes [...] --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com> Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: project-defiant <[email protected]> Co-authored-by: Irene López Santiago <[email protected]> Co-authored-by: Daniel Suveges <[email protected]> Co-authored-by: Yakov <[email protected]>
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feat: change betas to posterior mean from susie for Finngen credible …
…sets (opentargets#872) * feat: using mean instead of univariate beta * fix: missing f-string * fix: typo * fix: beta column in locus * feat: populating locusStart and locusEnd from region column * fix: locusStart/End cast to integer --------- Co-authored-by: Yakov <[email protected]>
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feat: step to export disease/target evidence (opentargets#867)
* feature(l2g): step to export disease/target evidence * fix: sorting out typo in function docstring * fix: evidence is written as json * fix: addressing reviewer comments * docs: adding step documentation * chore: pre-commit auto fixes [...] * fix: removing default value from step definition --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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feat(variant_index): hash variants at the time of instance creation (o…
…pentargets#874) * fix(variant_index): pass config threshold after joining with gnomad * feat(dataset): ability to pass class params to `from_parquet` * feat(variant_index): hash variants after initialising class * test: ensure hashing happens and params are correcly separated * fix: add threshold in `test_extract_variant_index_from_vep` * feat(variant_index): make hash threshold inclusive
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Commits on Oct 25, 2024
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feat(l2g_feature_matrix): add
credibleSetConfidence
to L2G (opentar……gets#875) * feat(feature_matrix): add `credibleSetConfidence` * feat: add feature to l2g * test: add semantic and minor fixes * test: fix * test: fix
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feat(l2g): normalise distance features (opentargets#878)
* feat(l2g): normalise distance features * feat(l2g): normalise distance features * chore: fix tests
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feat: l2g feature to indicate if gene is protein-coding or not (opent…
…argets#873) * feat: l2g feature to indicate if gene is protein-coding or not * chore: pre-commit auto fixes [...] * fix: remove print from tests * fix: remove print from tests * fix: correct window size for gene annotation * fix: test error with MkDocs * fix: rename feature to remove range --------- Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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feat: making credset qc have an option to coalsce and deduplicate cre…
…dible sets without ld pruning (opentargets#877) * feat: making credset qc have an option to coalsce and deduplicate credible sets without ld pruning * fix: adding recursiveFileLookup for reading credible sets * Update src/gentropy/credible_set_qc.py Co-authored-by: Szymon Szyszkowski <[email protected]> * Update src/gentropy/method/susie_inf.py Co-authored-by: Szymon Szyszkowski <[email protected]> * Update src/gentropy/method/susie_inf.py Co-authored-by: Szymon Szyszkowski <[email protected]> * chore: pre-commit auto fixes [...] * fix: few typos from review * fix: if statement tweaks --------- Co-authored-by: Yakov <[email protected]> Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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test(study_locus) credible_set_qc step integration test (opentargets#880
) * test(credible_set_qc_step): added main functionality test * chore: moved default values to step config * chore: ensure to save with study locus schema * chore: enhanced docs * docs(credible_set_qc_ste): docs page * chore: typo --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat: flagging duplicated entries while keeping one of the duplicates (…
…opentargets#876) * feat: flagging duplicated entries while keeping one of the duplicates * feat: turning validation on for validation step * fix: test for duplication flagging * fix: test for duplication flagging --------- Co-authored-by: Yakov <[email protected]>
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feat: flag and filter credible sets (opentargets#879)
* feat(flag_and_filter_credible_sets): add code for identifying abnormal credible sets * feat(flag_and_filter_credible_sets): restructure tests * chore(flag_and_filter_credible_sets): update schema for spark loading * feat(flag_and_filter_credible_sets): first comple draft filtering abnormal pips code * fix(flag_and_filter_credible_sets): tweak broken code and unresolved merge * fix(flag_and_filter_credible_sets): amend test logic * fix(flag_and_filter_credible_sets): modify logic to simplify and account for floating point errors * chore(flag_and_filter_credible_sets): simplify logic to boolean
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build(deps-dev): bump ipython from 8.28.0 to 8.29.0 (opentargets#883)
Bumps [ipython](https://github.com/ipython/ipython) from 8.28.0 to 8.29.0. - [Release notes](https://github.com/ipython/ipython/releases) - [Commits](ipython/ipython@8.28.0...8.29.0) --- updated-dependencies: - dependency-name: ipython dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]>
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build(deps-dev): bump mypy from 1.12.1 to 1.13.0 (opentargets#884)
Bumps [mypy](https://github.com/python/mypy) from 1.12.1 to 1.13.0. - [Changelog](https://github.com/python/mypy/blob/master/CHANGELOG.md) - [Commits](python/mypy@v1.12.1...v1.13.0) --- updated-dependencies: - dependency-name: mypy dependency-type: direct:development update-type: version-update:semver-minor ... Signed-off-by: dependabot[bot] <[email protected]> Co-authored-by: dependabot[bot] <49699333+dependabot[bot]@users.noreply.github.com>
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Commits on Oct 31, 2024
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feat(trainer): log model explanation with shap (opentargets#886)
* build: add `shap` * feat(l2g): log feature contributions with shap * chore: update lock file * fix: ignore installed packages in `install_dependencies_on_cluster.sh` (problem with llvm) * build: add `matplotlib` * fix: pin `matplotlib` version to avoid mplDeprecation issue * fix(trainer): set default features_list + minor bugs * chore: pre-commit auto fixes [...]
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chore: pre-commit autoupdate (opentargets#885)
updates: - [github.com/astral-sh/ruff-pre-commit: v0.7.0 → v0.7.1](astral-sh/ruff-pre-commit@v0.7.0...v0.7.1) - [github.com/pre-commit/mirrors-mypy: v1.12.1 → v1.13.0](pre-commit/mirrors-mypy@v1.12.1...v1.13.0) Co-authored-by: pre-commit-ci[bot] <66853113+pre-commit-ci[bot]@users.noreply.github.com>
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fix(distance_features): correct mean distance equation and correct ro…
…ws with negative values (opentargets#889) * fix(distance_features): hack to set to null negative values * fix(distance_features): correct mean distance equation
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feat: add step to generate association data (opentargets#888)
* feat: add step to generate association data * fix: evidence input file is json * feat: changed maximum theoretical harmonic sum formula * test: add test for calculate_harmonic_sum function * chore: move calculate_harmonic_sum function to spark_helpers.py * chore: update import statement
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fix: revert distinct for associations input file (opentargets#871)
* fix: revert distinct for associations input file * refactor: rename the temporary studyLocusId to rowId * refactor: rename the temporary studyLocusId to rowId in test * revert: add back assign_study_locus_id in window_baased_clumping as required for SummaryStatistics --------- Co-authored-by: Daniel Suveges <[email protected]>
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feat: add effect size direction to coloc output (opentargets#854)
* feat(coloc effect sizes): add calculate beta ratio method * feat(coloc effect sizes): update schema and coloc code * fix(coloc effect sizes): tweak beta ratio return * chore: tweak colocalisation schema * feat(coloc_effect_sizes): add simple test * fix(coloc_effect_sizes): change variable to camel case * fix: test broken * feat: remove zero betas too * chore: stylistic changes --------- Co-authored-by: Daniel Suveges <[email protected]>
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refactor(convert to vcf): allow multiple input sources (opentargets#891)
* refactor(convert to vcf step): parse variants from multiple data sources * chore(config): align config * fix: pass write mode from session * feat: allow for 2 columns to create partitions --------- Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat: deconvolute studies upon ingestion of GWAS Catalog datasets (op…
…entargets#887) * feat: adding logic to deconvolute studies with the same id * fix: import type * fix: import again * fix: flagging condition * feat: adding flag to gwas catalog studies to indicate no summary statistics * feat: adding flags for gwas catalog hop hit ingestion * feat: remove not curated flag if no sumstats available * fix: removing test for duplicated study locus * fix: changing flag name to clarify meaning * fix: flagging condition
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fix(
credibleSetConfidence
): inner join between study locus and vari……ant index to avoid null genes (opentargets#890)
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feat(feature_matrix): impute values for gene attribute cols (opentarg…
…ets#895) * feat(feature_matrix): impute values for gene attribute cols + semantic test * fix: change window * chore: fill na in the feature matrix generation step
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feat: adding l2g features to prediction table (opentargets#899)
* feat: adding l2g features to prediction table * fix: renaming method for better name * fix: remove show statement * fix: dropping locusToGeneFeatures if already exist * feat: dropping features with null values from the map
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fix: ensure the #CHROM is not quoted (opentargets#896)
Co-authored-by: Szymon Szyszkowski <[email protected]> Co-authored-by: Daniel Suveges <[email protected]>
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fix: do not impute
isProteinCoding
(opentargets#902)* fix: fix col names for imputation * fix: fix v1 * fix: test
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fix: reclassify eqtl catalogue sc datasets (opentargets#894)
* fix: tweak sc vs bulk eqtl catalogue logic * fix: update tests * fix: correct coloc calling of method * fix: address PR comments * fix: change string to col * fix: change eqtl catalogue path to specific commit * chore: fix method description
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fix: using the 99% PIP cs column, (opentargets#904)
* feat: changing to 99 credible sets * fix: change summary schema * fix: adding purity metrics * fix: updating test data samples * fix: updating test data samples * Update finemapping.py
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Commits on Nov 8, 2024
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refactor: finemapping method enum (opentargets#897)
Co-authored-by: Yakov <[email protected]>
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Commits on Nov 11, 2024
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feat: extract pos and chromosome from variantid (opentargets#909)
Co-authored-by: Szymon Szyszkowski <[email protected]>
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feat: changes to PICS credible sets (OUT_OF_SAMPLE_LD QC flag and cap…
…ital PICS) (opentargets#910) * feat: add OUT_OF_SAMPLE_LD QC flag to PICS credible sets * feat: change pics finemapping method to PICS * test: change pics to PICS in test data * fix: flag studies without sumstats without relying on hasSumstats column * fix: flag studies without sumstats without using update_quality_flag function
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