TASK-6565 Ensure the CellBase DB adaptors are updated to reflect the latest data releases

cellbase-app/src/main/java/org/opencb/cellbase/app/cli/admin/executors/LoadCommandExecutor.java

@@ -411,14 +411,14 @@ private void loadVariationData() throws NoSuchMethodException, InterruptedExcept
         if (dbSnpFilePath.toFile().exists()) {
             if (variationPath.resolve(DBSNP_VERSION_FILENAME).toFile().exists()) {
                 logger.info("Loading dbSNP file '{}'", dbSnpFilePath);
-                loadRunner.load(dbSnpFilePath, SNP_COLLECTION_NAME, dataRelease);
+                loadRunner.load(dbSnpFilePath, SNP_DATA, dataRelease);
 
                 // Create index
-                createIndex(SNP_COLLECTION_NAME);
+                createIndex(SNP_DATA);
 
                 // Update release (collection and sources)
                 List<Path> sources = Collections.singletonList(variationPath.resolve(DBSNP_VERSION_FILENAME));
-                dataReleaseManager.update(dataRelease, SNP_COLLECTION_NAME, EtlCommons.VARIATION_DATA, sources);
+                dataReleaseManager.update(dataRelease, SNP_DATA, EtlCommons.VARIATION_DATA, sources);
             } else {
                 logger.warn("In order to load the dbSNP file you need the version file {} within the folder '{}'", DBSNP_VERSION_FILENAME,
                         variationPath);

cellbase-app/src/main/java/org/opencb/cellbase/app/cli/admin/executors/ValidationCommandExecutor.java

@@ -66,7 +66,7 @@ public ValidationCommandExecutor(AdminCliOptionsParser.ValidationCommandOptions
     }
 
     @Override
-    public void execute() {
+    public void execute() throws CellBaseException {
         checkFilesExist();
 
         VariantAnnotationCalculator variantAnnotationCalculator;

cellbase-core/src/main/resources/configuration.yml

@@ -122,7 +122,10 @@ download:
 #    host: https://ftp.ncbi.nlm.nih.gov/pub/clinvar/xml/clinvar_variation/ClinVarVariationRelease_2022-11.xml.gz
     host: https://ftp.ncbi.nlm.nih.gov/pub/clinvar/xml/VCV_xml_old_format/ClinVarVariationRelease_2024-05.xml.gz
     version: 2024-05
+<<<<<<< HEAD
+=======
 >>>>>>> release-6.2.x
+>>>>>>> release-6.x.x
   clinvarSummary:
     host: http://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/variant_summary.txt.gz
   clinvarVariationAllele:
@@ -147,15 +150,21 @@ download:
   genomicSuperDups:
     host: http://hgdownload.cse.ucsc.edu/goldenPath
   gwasCatalog:
+<<<<<<< HEAD
+=======
 <<<<<<< HEAD
     host: http://resources.opencb.org/opencb/cellbase/data/gwas/gwas_catalog_v1.0.2-associations_e106_r2022-05-17.tsv
     version: "1.0.2 associations_e106_r2022-05-17"
 =======
+>>>>>>> release-6.x.x
     #host: http://resources.opencb.org/opencb/cellbase/data/gwas/gwas_catalog_v1.0.2-associations_e106_r2022-05-17.tsv
     host: "https://ftp.ebi.ac.uk/pub/databases/gwas/releases/2024/05/20/gwas-catalog-associations_ontology-annotated.tsv"
     #version: "1.0.2 associations_e106_r2022-05-17"
     version: "2024-05-20"
+<<<<<<< HEAD
+=======
 >>>>>>> release-6.2.x
+>>>>>>> release-6.x.x
   hpo:
     host: https://ci.monarchinitiative.org/view/hpo/job/hpo.annotations/lastSuccessfulBuild/artifact/rare-diseases/util/annotation/phenotype_to_genes.txt
   disgenet:

cellbase-lib/src/main/java/org/opencb/cellbase/lib/EtlCommons.java

@@ -38,6 +38,7 @@ public class EtlCommons {
     public static final String HOMO_SAPIENS_NAME ="Homo sapiens";
 
     public static final String GENOME_DATA = "genome";
+    public static final String GENOME_SEQUENCE_DATA = "genome_sequence";
     public static final String GENE_DATA = "gene";
     public static final String REFSEQ_DATA = "refseq";
     public static final String GENE_DISEASE_ASSOCIATION_DATA = "gene_disease_association";
@@ -69,7 +70,7 @@ public class EtlCommons {
     public static final String DBSNP_FILE = "GCF_000001405.40.gz";
     public static final String DBSNP_NAME = "dbSNP";
     public static final String DBSNP_VERSION_FILENAME = DBSNP_NAME + "Version.json";
-    public static final String SNP_COLLECTION_NAME = "snp";
+    public static final String SNP_DATA = "snp";
 
     public static final String STRUCTURAL_VARIANTS_DATA = "svs";
     public static final String REPEATS_DATA = "repeats";
@@ -79,6 +80,8 @@ public class EtlCommons {
     public static final String DOID_FILE = "doid.obo";
     public static final String PFM_DATA = "regulatory_pfm";
 
+    public static final String REGULATORY_REGION_DATA = "regulatory_region";
+
     // Build specific data options
     public static final String GENOME_INFO_DATA = "genome_info";
     public static final String DISGENET_DATA = "disgenet";

cellbase-lib/src/main/java/org/opencb/cellbase/lib/impl/core/CellBaseDBAdaptor.java

@@ -16,76 +16,25 @@
 
 package org.opencb.cellbase.lib.impl.core;
 
-import org.apache.commons.collections4.CollectionUtils;
 import org.opencb.cellbase.core.exception.CellBaseException;
-import org.opencb.cellbase.core.models.DataRelease;
+import org.opencb.cellbase.lib.impl.core.singleton.DataReleaseSingleton;
 import org.opencb.commons.datastore.mongodb.MongoDBCollection;
 import org.opencb.commons.datastore.mongodb.MongoDataStore;
 
-import java.util.HashMap;
-import java.util.List;
-import java.util.Map;
-
 public class CellBaseDBAdaptor extends MongoDBAdaptor {
 
-    protected List<DataRelease> dataReleases;
-    protected Map<Integer, MongoDBCollection> mongoDBCollectionByRelease;
-
     public static final String DATA_RELEASE_SEPARATOR = "__v";
 
-    public static String buildCollectionName(String data, int release) {
-        String name = data + DATA_RELEASE_SEPARATOR + release;
-        return name;
-    }
-
-    public Map<Integer, MongoDBCollection> buildCollectionByReleaseMap(String data) {
-        Map<Integer, MongoDBCollection> collectionMap = new HashMap<>();
-        if (CollectionUtils.isNotEmpty(dataReleases)) {
-            for (DataRelease dataRelease : dataReleases) {
-                if (dataRelease.getCollections().containsKey(data)) {
-                    String collectionName = dataRelease.getCollections().get(data);
-                    collectionMap.put(dataRelease.getRelease(), mongoDataStore.getCollection(collectionName));
-                }
-            }
-        } else {
-            // For backward compatibility (i.e., in case data_release collection is missing)
-            collectionMap.put(0, mongoDataStore.getCollection(data));
-        }
-
-        return collectionMap;
-    }
-
-    public MongoDBCollection getCollectionByRelease(Map<Integer, MongoDBCollection> collectionMap, Integer dataRelease)
-            throws CellBaseException {
-        int release = dataRelease == null ? 0 : dataRelease;
-        if (!collectionMap.containsKey(release)) {
-            // If the data release is invalid, throw an exception
-            String msg = "Data not found in release " + release + ". " + collectionMap.toString();
-            logger.error(msg);
-            throw new CellBaseException(msg);
-        }
-        return collectionMap.get(release);
-    }
-
     public CellBaseDBAdaptor(MongoDataStore mongoDataStore) {
         super(mongoDataStore);
-        this.dataReleases = new ReleaseMongoDBAdaptor(mongoDataStore).getAll().getResults();
-    }
-
-    @Override
-    public String toString() {
-        final StringBuilder sb = new StringBuilder("CellBaseDBAdaptor{");
-        sb.append("dataRelease=").append(dataReleases);
-        sb.append('}');
-        return sb.toString();
     }
 
-    public List<DataRelease> getDataReleases() {
-        return dataReleases;
+    public static String buildCollectionName(String data, int release) {
+        String name = data + DATA_RELEASE_SEPARATOR + release;
+        return name;
     }
 
-    public CellBaseDBAdaptor setDataReleases(List<DataRelease> dataReleases) {
-        this.dataReleases = dataReleases;
-        return this;
+    public MongoDBCollection getMongoDBCollection(String data, int release) throws CellBaseException {
+        return DataReleaseSingleton.getInstance().getMongoDBCollection(mongoDataStore.getDatabaseName(), data, release);
     }
 }

cellbase-lib/src/main/java/org/opencb/cellbase/lib/impl/core/ClinicalMongoDBAdaptor.java

@@ -46,6 +46,7 @@
 import java.util.function.Consumer;
 
 import static org.opencb.cellbase.core.ParamConstants.DATA_RELEASE_PARAM;
+import static org.opencb.cellbase.lib.EtlCommons.CLINICAL_VARIANTS_DATA;
 
 /**
  * Created by fjlopez on 06/12/16.
@@ -65,14 +66,6 @@ public ClinicalMongoDBAdaptor(MongoDataStore mongoDataStore, GenomeManager genom
         super(mongoDataStore);
 
         this.genomeManager = genomeManager;
-
-        init();
-    }
-
-    private void init() {
-        logger.debug("ClinicalMongoDBAdaptor: in 'constructor'");
-
-        mongoDBCollectionByRelease = buildCollectionByReleaseMap("clinical_variants");
     }
 
     public CellBaseDataResult<Variant> next(Query query, QueryOptions options) {
@@ -103,16 +96,14 @@ public CellBaseDataResult getIntervalFrequencies(Query query, int intervalSize,
     public CellBaseDataResult<Long> count(Query query) throws CellBaseException {
         Bson bson = parseQuery(query);
 
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease,
-                (Integer) query.getOrDefault(DATA_RELEASE_PARAM, 0));
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(CLINICAL_VARIANTS_DATA, query.getInt(DATA_RELEASE_PARAM));
         return new CellBaseDataResult<>(mongoDBCollection.count(bson));
     }
 
     public CellBaseDataResult distinct(Query query, String field) throws CellBaseException {
         Bson bson = parseQuery(query);
 
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease,
-                (Integer) query.getOrDefault(DATA_RELEASE_PARAM, 0));
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(CLINICAL_VARIANTS_DATA, query.getInt(DATA_RELEASE_PARAM));
         return new CellBaseDataResult<>(mongoDBCollection.distinct(field, bson));
     }
 
@@ -128,8 +119,7 @@ public CellBaseDataResult<Variant> get(Query query, QueryOptions options) throws
         logger.debug("query: {}", bson.toBsonDocument().toJson());
         logger.debug("queryOptions: {}", options.toJson());
 
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease,
-                (Integer) query.getOrDefault(DATA_RELEASE_PARAM, 0));
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(CLINICAL_VARIANTS_DATA, query.getInt(DATA_RELEASE_PARAM));
         return new CellBaseDataResult<>(mongoDBCollection.find(bson, null, Variant.class, parsedOptions));
     }
 
@@ -140,8 +130,7 @@ public CellBaseDataResult nativeGet(Query query, QueryOptions options) throws Ce
         logger.debug("query: {}", bson.toBsonDocument().toJson());
         logger.debug("queryOptions: {}", options.toJson());
 
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease,
-                (Integer) query.getOrDefault(DATA_RELEASE_PARAM, 0));
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(CLINICAL_VARIANTS_DATA, query.getInt(DATA_RELEASE_PARAM));
         return new CellBaseDataResult<>(mongoDBCollection.find(bson, parsedOptions));
     }
 
@@ -152,8 +141,7 @@ public Iterator<Variant> iterator(Query query, QueryOptions options) {
     public Iterator nativeIterator(Query query, QueryOptions options) throws CellBaseException {
         Bson bson = parseQuery(query);
 
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease,
-                (Integer) query.getOrDefault(DATA_RELEASE_PARAM, 0));
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(CLINICAL_VARIANTS_DATA, query.getInt(DATA_RELEASE_PARAM));
         return mongoDBCollection.nativeQuery().find(bson, options);
     }
 
@@ -355,7 +343,7 @@ private CellBaseDataResult getClinvarPhenotypeGeneRelations(QueryOptions queryOp
         fields.put("associatedGenes", 1);
         pipeline.add(new Document("$project", fields));
 
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease, dataRelease);
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(CLINICAL_VARIANTS_DATA, dataRelease);
         return executeAggregation2("", pipeline, queryOptions, mongoDBCollection);
 
     }
@@ -377,7 +365,7 @@ private CellBaseDataResult getGwasPhenotypeGeneRelations(QueryOptions queryOptio
         fields.put("associatedGenes", 1);
         pipeline.add(new Document("$project", fields));
 
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease, dataRelease);
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(CLINICAL_VARIANTS_DATA, dataRelease);
         return executeAggregation2("", pipeline, queryOptions, mongoDBCollection);
     }
 
@@ -466,7 +454,7 @@ public CellBaseIterator iterator(ClinicalVariantQuery query) throws CellBaseExce
         Bson projection = getProjection(query);
         GenericDocumentComplexConverter<Variant> converter = new GenericDocumentComplexConverter<>(Variant.class);
 
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease, query.getDataRelease());
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(CLINICAL_VARIANTS_DATA, query.getDataRelease());
         MongoDBIterator<Variant> iterator = mongoDBCollection.iterator(null, bson, projection, converter, queryOptions);
         return new CellBaseMongoDBIterator<>(iterator);
     }

cellbase-lib/src/main/java/org/opencb/cellbase/lib/impl/core/GeneMongoDBAdaptor.java

@@ -32,6 +32,7 @@
 import org.opencb.cellbase.core.api.query.ProjectionQueryOptions;
 import org.opencb.cellbase.core.exception.CellBaseException;
 import org.opencb.cellbase.core.result.CellBaseDataResult;
+import org.opencb.cellbase.lib.EtlCommons;
 import org.opencb.cellbase.lib.MongoDBCollectionConfiguration;
 import org.opencb.cellbase.lib.iterator.CellBaseIterator;
 import org.opencb.cellbase.lib.iterator.CellBaseMongoDBIterator;
@@ -43,13 +44,15 @@
 import java.util.*;
 import java.util.regex.Pattern;
 
+import static org.opencb.cellbase.lib.EtlCommons.GENE_DATA;
+
 /**
  * Created by imedina on 25/11/15.
  */
 public class GeneMongoDBAdaptor extends CellBaseDBAdaptor implements CellBaseCoreDBAdaptor<GeneQuery, Gene> {
 
     private static final Set<String> CONSTRAINT_NAMES = new HashSet<>();
-    private Map<Integer, MongoDBCollection> refseqCollectionByRelease;
+//    private Map<Integer, MongoDBCollection> refseqCollectionByRelease;
 
     private static final GenericDocumentComplexConverter<Gene> CONVERTER;
 
@@ -66,15 +69,15 @@ public class GeneMongoDBAdaptor extends CellBaseDBAdaptor implements CellBaseCor
     public GeneMongoDBAdaptor(MongoDataStore mongoDataStore) {
         super(mongoDataStore);
 
-        this.init();
+//        this.init();
     }
 
-    private void init() {
-        mongoDBCollectionByRelease = buildCollectionByReleaseMap("gene");
-        refseqCollectionByRelease = buildCollectionByReleaseMap("refseq");
-
-        logger.debug("GeneMongoDBAdaptor initialised");
-    }
+//    private void init() {
+//        mongoDBCollectionByRelease = buildCollectionByReleaseMap("gene");
+//        refseqCollectionByRelease = buildCollectionByReleaseMap("refseq");
+//
+//        logger.debug("GeneMongoDBAdaptor initialised");
+//    }
 
     @Override
     public CellBaseDataResult<Gene> aggregationStats(GeneQuery query) {
@@ -97,10 +100,10 @@ public List<CellBaseDataResult<Gene>> info(List<String> ids, ProjectionQueryOpti
             orBsonList.add(Filters.eq("name", id));
             Bson query = Filters.or(orBsonList);
             if (StringUtils.isEmpty(source) || ParamConstants.QueryParams.ENSEMBL.key().equalsIgnoreCase(source)) {
-                MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease, dataRelease);
+                MongoDBCollection mongoDBCollection = getMongoDBCollection(GENE_DATA, dataRelease);
                 results.add(new CellBaseDataResult<>(mongoDBCollection.find(query, projection, CONVERTER, new QueryOptions())));
             } else {
-                MongoDBCollection mongoDBCollection = getCollectionByRelease(refseqCollectionByRelease, dataRelease);
+                MongoDBCollection mongoDBCollection = getMongoDBCollection(EtlCommons.REFSEQ_DATA, dataRelease);
                 results.add(new CellBaseDataResult<>(mongoDBCollection.find(query, projection, CONVERTER, new QueryOptions())));
             }
         }
@@ -115,10 +118,10 @@ public CellBaseIterator<Gene> iterator(GeneQuery query) throws CellBaseException
         MongoDBIterator<Gene> iterator;
         if (query.getSource() != null && !query.getSource().isEmpty() && ParamConstants.QueryParams.REFSEQ.key()
                 .equalsIgnoreCase(query.getSource().get(0))) {
-            MongoDBCollection mongoDBCollection = getCollectionByRelease(refseqCollectionByRelease, query.getDataRelease());
+            MongoDBCollection mongoDBCollection = getMongoDBCollection(EtlCommons.REFSEQ_DATA, query.getDataRelease());
             iterator = mongoDBCollection.iterator(null, bson, projection, CONVERTER, queryOptions);
         } else {
-            MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease, query.getDataRelease());
+            MongoDBCollection mongoDBCollection = getMongoDBCollection(GENE_DATA, query.getDataRelease());
             iterator = mongoDBCollection.iterator(null, bson, projection, CONVERTER, queryOptions);
         }
         return new CellBaseMongoDBIterator<>(iterator);
@@ -127,15 +130,15 @@ public CellBaseIterator<Gene> iterator(GeneQuery query) throws CellBaseException
     @Override
     public CellBaseDataResult<String> distinct(GeneQuery geneQuery) throws CellBaseException {
         Bson bsonDocument = parseQuery(geneQuery);
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease, geneQuery.getDataRelease());
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(GENE_DATA, geneQuery.getDataRelease());
         return new CellBaseDataResult<>(mongoDBCollection.distinct(geneQuery.getFacet(), bsonDocument, String.class));
     }
 
     @Override
     public CellBaseDataResult<Gene> groupBy(GeneQuery geneQuery) throws CellBaseException {
         Bson bsonQuery = parseQuery(geneQuery);
         logger.info("geneQuery: {}", bsonQuery.toBsonDocument().toJson());
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease, geneQuery.getDataRelease());
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(GENE_DATA, geneQuery.getDataRelease());
         return groupBy(bsonQuery, geneQuery, "name", mongoDBCollection);
     }
 
@@ -157,7 +160,7 @@ public CellBaseDataResult<Gene> startsWith(String id, QueryOptions options, int
                 projection = Projections.exclude("transcripts", "annotation");
             }
         }
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease, dataRelease);
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(GENE_DATA, dataRelease);
         return new CellBaseDataResult<>(mongoDBCollection.find(regex, projection, CONVERTER, options));
     }
 
@@ -355,7 +358,7 @@ public CellBaseDataResult<TranscriptTfbs> getTfbs(String geneId, QueryOptions qu
         List<Bson> pipeline = unwindAndMatchTranscripts(query, queryOptions);
         GenericDocumentComplexConverter<TranscriptTfbs> converter = new GenericDocumentComplexConverter<>(TranscriptTfbs.class);
 
-        MongoDBCollection mongoDBCollection = getCollectionByRelease(mongoDBCollectionByRelease, dataRelease);
+        MongoDBCollection mongoDBCollection = getMongoDBCollection(GENE_DATA, dataRelease);
         MongoDBIterator<TranscriptTfbs> iterator = mongoDBCollection.iterator(pipeline, converter, queryOptions);
 
         List<TranscriptTfbs> tfbs = new ArrayList<>();