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27 changes: 27 additions & 0 deletions
27
app/integration_test/fixtures/guidelines/aripiprazole_cyp2d6_poor.dart
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,27 @@ | ||
| import 'package:app/common/models/drug/guideline.dart'; | ||
| import 'package:app/common/models/drug/warning_level.dart'; | ||
|
|
||
| final aripiprazoleCyp2d6PoorGuideline = Guideline( | ||
| id: '6492f8e9918ddcae7349c304', | ||
| version: 1, | ||
| lookupkey: { | ||
| 'CYP2D6': ['0.0'], | ||
| }, | ||
| externalData: [ | ||
| GuidelineExtData( | ||
| source: 'FDA', | ||
| guidelineName: 'Table of Pharmacogenetic Associations (Section 1)', | ||
| guidelineUrl: 'https://www.fda.gov/medical-devices/precision-medicine/table-pharmacogenetic-associations#section1', | ||
| implications: { | ||
| 'CYP2D6': 'Results in higher systemic concentrations and higher adverse reaction risk. Dosage adjustment is recommended. Refer to FDA labeling for specific dosing recommendations.', | ||
| }, | ||
| recommendation: 'Might be included in implication text (imported from FDA, source only states one text per guideline)', | ||
| comments: null, | ||
| ), | ||
| ], | ||
| annotations: GuidelineAnnotations( | ||
| implication: 'You break down aripiprazole slower than expected. You have an increased risk for side effects.', | ||
| recommendation: 'Aripiprazole may be used at a lower dose. Consult your pharmacist or doctor for more information.', | ||
| warningLevel: WarningLevel.yellow, | ||
| ), | ||
| ); |
27 changes: 27 additions & 0 deletions
27
app/integration_test/fixtures/guidelines/guideline.dart.template
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,27 @@ | ||
| import 'package:app/common/models/drug/guideline.dart'; | ||
| import 'package:app/common/models/drug/warning_level.dart'; | ||
|
|
||
| final nonCompilingPlaceholdersGuideline = Guideline( | ||
| id: null, | ||
| version: null, | ||
| lookupkey: { | ||
| null: [null], | ||
| }, | ||
| externalData: [ | ||
| GuidelineExtData( | ||
| source: null, | ||
| guidelineName: null, | ||
| guidelineUrl: null, | ||
| implications: { | ||
| null: null, | ||
| }, | ||
| recommendation: null, | ||
| comments: null, | ||
| ), | ||
| ], | ||
| annotations: GuidelineAnnotations( | ||
| implication: null, | ||
| recommendation: null, | ||
| warningLevel: WarningLevel.null, | ||
| ), | ||
| ); |
29 changes: 29 additions & 0 deletions
29
...tegration_test/fixtures/guidelines/pazopanib_hlab5701_positive_ugt1a1_poor_guideline.dart
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,29 @@ | ||
| import 'package:app/common/models/drug/guideline.dart'; | ||
| import 'package:app/common/models/drug/warning_level.dart'; | ||
|
|
||
| final pazopanibHlab5701PositiveUgt1a1PoorGuideline = Guideline( | ||
| id: '6686a865826414ec5b05c436', | ||
| version: 1, | ||
| lookupkey: { | ||
| 'HLA-B': ['*57:01 positive'], | ||
| 'UGT1A1': ['Poor Metabolizer'], | ||
| }, | ||
| externalData: [ | ||
| GuidelineExtData( | ||
| source: 'FDA', | ||
| guidelineName: 'Table of Pharmacogenetic Associations (Section 2)', | ||
| guidelineUrl: 'https://www.fda.gov/medical-devices/precision-medicine/table-pharmacogenetic-associations#section2', | ||
| implications: { | ||
| 'HLA-B': 'May result in higher adverse reaction risk (liver enzyme elevations). Monitor liver function tests regardless of genotype.', | ||
| 'UGT1A1': 'Results in higher adverse reaction risk (hyperbilirubinemia).', | ||
| }, | ||
| recommendation: 'Might be included in implication text (imported from FDA, source only states one text per guideline)', | ||
| comments: null, | ||
| ), | ||
| ], | ||
| annotations: GuidelineAnnotations( | ||
| implication: 'You have an increased risk for side effects. (Test case 1)', | ||
| recommendation: 'You can still use pazopanib at standard dose. Consult your pharmacist or doctor for more information. (Test case 1)', | ||
| warningLevel: WarningLevel.yellow, | ||
| ), | ||
| ); |
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| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,92 @@ | ||
| import 'package:app/common/module.dart'; | ||
| import 'package:app/report/module.dart'; | ||
| import 'package:flutter_localizations/flutter_localizations.dart'; | ||
| import 'package:flutter_test/flutter_test.dart'; | ||
| import 'package:integration_test/integration_test.dart'; | ||
| import 'package:provider/provider.dart'; | ||
|
|
||
| import 'fixtures/guidelines/aripiprazole_cyp2d6_poor.dart'; | ||
| import 'fixtures/guidelines/pazopanib_hlab5701_positive_ugt1a1_poor_guideline.dart'; | ||
| import 'fixtures/set_user_data.dart'; | ||
|
|
||
| void main() { | ||
| final binding = IntegrationTestWidgetsFlutterBinding.ensureInitialized(); | ||
| binding.framePolicy = LiveTestWidgetsFlutterBindingFramePolicy.onlyPumps; | ||
|
|
||
| setUp(() { | ||
| UserData.instance.labData = null; | ||
| UserData.instance.genotypeResults = null; | ||
| }); | ||
|
|
||
| Future<void> loadReportPage(WidgetTester tester) async { | ||
| await tester.pumpWidget( | ||
| ChangeNotifierProvider( | ||
| create: (context) => ActiveDrugs(), | ||
| child: MaterialApp( | ||
| home: Scaffold( | ||
| body: Builder( | ||
| builder: (context) { | ||
| return ReportPage(); | ||
| }, | ||
| ), | ||
| ), | ||
| localizationsDelegates: [ | ||
| AppLocalizations.delegate, | ||
| GlobalMaterialLocalizations.delegate, | ||
| GlobalWidgetsLocalizations.delegate, | ||
| GlobalCupertinoLocalizations.delegate, | ||
| ], | ||
| supportedLocales: [Locale('en', '')], | ||
| ), | ||
| ), | ||
| ); | ||
| } | ||
|
|
||
| Future<void> testReportContent( | ||
| WidgetTester tester, { | ||
| required List<Guideline> expectedGuidelines, | ||
| required List<GenotypeResult> missingResults, | ||
| }) async { | ||
| expectedGuidelines.forEach(setUserDataForGuideline); | ||
| missingResults.forEach(setGenotypeResult); | ||
| await loadReportPage(tester); | ||
| final expectedGenes = [ | ||
| ...expectedGuidelines.flatMap( | ||
| (guideline) => guideline.lookupkey.keys | ||
| ), | ||
| ...missingResults.map((genotypeResult) => genotypeResult.gene), | ||
| ]; | ||
| expect( | ||
| find.byType(GeneCard, skipOffstage: false), | ||
| findsNWidgets(expectedGenes.length), | ||
| ); | ||
| for (final gene in expectedGenes.toSet()) { | ||
| final expectedGeneOccurrences = | ||
| expectedGenes.count((expectedGene) => expectedGene == gene); | ||
| expect( | ||
| find.textContaining(gene, skipOffstage: false), | ||
| findsNWidgets(expectedGeneOccurrences), | ||
| ); | ||
| } | ||
| } | ||
|
|
||
| group('integration test for the report page', () { | ||
| testWidgets( | ||
| 'tests that genes for drugs with guidelines are shown', | ||
| (tester) async { | ||
| final expectedGuidelines = [ | ||
| aripiprazoleCyp2d6PoorGuideline, | ||
| pazopanibHlab5701PositiveUgt1a1PoorGuideline, | ||
| ]; | ||
| final missingResults = [ | ||
| GenotypeResult.missingResult('HLA-B', variant: '*15:02'), | ||
| ]; | ||
| await testReportContent( | ||
| tester, | ||
| expectedGuidelines: expectedGuidelines, | ||
| missingResults: missingResults, | ||
| ); | ||
| }, | ||
| ); | ||
| }); | ||
| } |
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