test(app): add test for specific no result guidelines

hpi-dhc · Sep 24, 2024 · 050e0b2 · 050e0b2
1 parent 033ebbd
commit 050e0b2
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Showing 4 changed files with 110 additions and 16 deletions.
diff --git a/app/integration_test/drugs_test.dart b/app/integration_test/drugs_test.dart
@@ -11,6 +11,7 @@ import 'fixtures/drugs/aripiprazole_with_any_not_handled_guideline.dart';
 import 'fixtures/drugs/ibuprofen_with_proper_guideline.dart';
 import 'fixtures/drugs/mirabegron_without_guidelines.dart';
 import 'fixtures/drugs/pazopanib_with_multiple_any_not_handled_fallback_guidelines.dart';
+import 'fixtures/drugs/rosuvastatin_with_no_result_guideline.dart';
 import 'fixtures/drugs/warfarin_with_any_fallback_guideline.dart';
 import 'fixtures/set_app_data.dart';
 import 'mocks/drug_cubit.dart';
@@ -160,21 +161,6 @@ void main() {
           findsOneWidget,
         );
       }
-      if (explicitNoResult != null) {
-        for (final noResultGene in explicitNoResult) {
-          final geneRowFinder = find.ancestor(
-            of: find.text(noResultGene),
-            matching: find.byType(Table),
-          );
-          expect(
-            find.descendant(
-              of: geneRowFinder,
-              matching: find.textContaining(context.l10n.general_not_tested),
-            ),
-            findsOneWidget,
-          );
-        }
-      }
     } else {
       expect(card.color, relevantGuideline!.annotations.warningLevel.color);
       expect(
@@ -208,6 +194,29 @@ void main() {
         }
       }
     }
+    final noResultGenes = [
+      ...(explicitNoResult ?? []),
+      ...(relevantGuideline?.lookupkey.entries.filter(
+        (lookupEntry) => lookupEntry.value.any(
+          (variant) => variant == SpecialLookup.noResult.value
+        )
+      ).map((lookupEntry) => lookupEntry.key).toList() ?? [])
+    ];
+    if (noResultGenes.isNotEmpty) {
+      for (final noResultGene in noResultGenes) {
+        final geneRowFinder = find.ancestor(
+          of: find.text(noResultGene),
+          matching: find.byType(Table),
+        );
+        expect(
+          find.descendant(
+            of: geneRowFinder,
+            matching: find.textContaining(context.l10n.general_not_tested),
+          ),
+          findsOneWidget,
+        );
+      }
+    }
   }
 
   Future<void> runTestCases(List<_TestCase> testCases) async {
@@ -308,6 +317,11 @@ void main() {
           },
           expectNoMappedGuidelines: true,
         ),
+        _TestCase(
+          description: 'mappable no result',
+          drug: rosuvastatinWithNoResultGuidelines,
+          expectNoMappedGuidelines: false,
+        ),
       ]);
     });
 

diff --git a/app/integration_test/fixtures/drugs/rosuvastatin_with_no_result_guideline.dart b/app/integration_test/fixtures/drugs/rosuvastatin_with_no_result_guideline.dart
@@ -0,0 +1,69 @@
+import 'package:app/common/models/drug/drug.dart';
+import 'package:app/common/models/drug/guideline.dart';
+import 'package:app/common/models/drug/warning_level.dart';
+
+final rosuvastatinWithNoResultGuidelines = Drug(
+  id: '6407768c92a4868065b6d18e',
+  version: 1,
+  name: 'rosuvastatin',
+  rxNorm: 'RxNorm:301542',
+  annotations: DrugAnnotations(
+    drugclass: 'Anti-cholesterol',
+    indication: 'Statins lower high cholesterol and triglyceride levels and reduce risk of heart related health conditions.',
+    brandNames: ['Crestor', 'Ezallor', 'Roszet'],
+  ),
+  guidelines: [
+    Guideline(
+      id: '64552859a1b68082babc8e09',
+      version: 1,
+      lookupkey: {
+        'ABCG2': ['No Result'],
+        'SLCO1B1': ['Normal Function'],
+      },
+      externalData: [
+        GuidelineExtData(
+          source: 'CPIC',
+          guidelineName: 'SLCO1B1, ABCG2, CYP2C9, and Statins',
+          guidelineUrl: 'https://cpicpgx.org/guidelines/cpic-guideline-for-statins/',
+          implications: {
+            'ABCG2': 'n/a',
+            'SLCO1B1': 'Typical myopathy risk and statin exposure',
+          },
+          recommendation: 'Based on SLCO1B1 status, prescribe desired starting dose and adjust doses based on disease-specific guidelines. ABCG2 genotype result is not available.',
+          comments: 'The potential for drug-drug interactions and dose limits based on renal and hepatic function and ancestry should be evaluated prior to initiating a statin.',
+        ),
+      ],
+      annotations: GuidelineAnnotations(
+        implication: 'You have a normal risk for side effects. (One missing)',
+        recommendation: 'You can use rosuvastatin at standard dose. Consult your pharmacist or doctor for more information. (One missing)',
+        warningLevel: WarningLevel.green,
+      ),  
+    ),
+    Guideline(
+      id: '64552859a1b68082babc8e14',
+      version: 1,
+      lookupkey: {
+        'ABCG2': ['Normal Function'],
+        'SLCO1B1': ['Normal Function'],
+      },
+      externalData: [
+        GuidelineExtData(
+          source: 'CPIC',
+          guidelineName: 'SLCO1B1, ABCG2, CYP2C9, and Statins',
+          guidelineUrl: 'https://cpicpgx.org/guidelines/cpic-guideline-for-statins/',
+          implications: {
+            'ABCG2': 'Typical myopathy risk and rosuvastatin exposure',
+            'SLCO1B1': 'Typical myopathy risk and statin exposure',
+          },
+          recommendation: 'Based on SLCO1B1 status, prescribe desired starting dose and adjust doses based on disease-specific guidelines. ABCG2 genotype result is not available.',
+          comments: 'The potential for drug-drug interactions and dose limits based on renal and hepatic function and ancestry should be evaluated prior to initiating a statin.',
+        ),
+      ],
+      annotations: GuidelineAnnotations(
+        implication: 'You have a normal risk for side effects. (Both normal)',
+        recommendation: 'You can use rosuvastatin at standard dose. Consult your pharmacist or doctor for more information. (Both normal)',
+        warningLevel: WarningLevel.green,
+      ),  
+    ),
+  ],
+);
diff --git a/app/integration_test/fixtures/set_app_data.dart b/app/integration_test/fixtures/set_app_data.dart
@@ -49,7 +49,9 @@ void setUserDataForGuideline(
     // multiple HLA-B variants in the tests or overwrite a specific HLA-B
     // variant, we will need to check for the genotype key (which is in the
     // current setup not possible without the proper variant)
-    if (!(explicitNoResult?.contains(gene) ?? false)) {
+    final lookupIsMissing = lookupkey == SpecialLookup.noResult.value ||
+      (explicitNoResult?.contains(gene) ?? false);
+    if (!lookupIsMissing) {
       UserData.instance.labData = UserData.instance.labData!.filter(
         (labResult) => labResult.gene != gene
       ).toList();

diff --git a/pharme.code-workspace b/pharme.code-workspace
@@ -32,6 +32,7 @@
   "settings": {
     "typescript.preferences.importModuleSpecifier": "relative",
     "cSpell.words": [
+      "ABCG",
       "Abilify",
       "abiraterone",
       "anni",
@@ -45,6 +46,7 @@
       "clopidogrel",
       "Coumadin",
       "CPIC",
+      "Crestor",
       "Cupertino",
       "dartx",
       "datetime",
@@ -56,6 +58,7 @@
       "drugid",
       "drugrecommendation",
       "duloxetine",
+      "Ezallor",
       "fluorouracil",
       "fullscreen",
       "haplotype",
@@ -80,6 +83,7 @@
       "Metabolizer",
       "mirabegron",
       "mocktail",
+      "myopathy",
       "Myrbetriq",
       "Neoprofen",
       "noto",
@@ -99,12 +103,17 @@
       "Proprinal",
       "pubspec",
       "RGBO",
+      "rosuvastatin",
+      "Roszet",
       "rxnorm",
       "screencast",
       "Screencasts",
       "screendocs",
       "sertraline",
       "simvastatin",
+      "SLCO",
+      "statin",
+      "Statins",
       "subfolders",
       "tacrolimus",
       "terbinafine",