update content

config/_default/menus.yaml

@@ -13,12 +13,9 @@ main:
   - name: Projects
     url: '#projects'
     weight: 30
-  - name: Talks
-    url: '#talks'
-    weight: 40
   - name: Publications
     url: '#publications'
-    weight: 50
+    weight: 40
 
 
 # Link to a PDF of your resume/CV from the menu.

content/authors/admin/_index.md

@@ -17,15 +17,15 @@ status:
 superuser: true
 
 # Role/position/tagline
-role: Questioning the Universe until it answers.
+role: Questioning the Universe until it answers, which happens sometime.
 
 # Organizations/Affiliations to show in About widget
 organizations:
   - name: The University of Edinburgh
     url: https://www.ed.ac.uk/
 
 # Short bio (displayed in user profile at end of posts)
-bio: Physicist mutated into a systems biophysicist aiming to understand how biological systems respond and adapt to critical conditions such as stress and injuries.
+bio: Biophysicist aiming to understand how biological systems respond and adapt to critical conditions such as stress and injuries.
 
 # Interests to show in About widget
 interests:
@@ -34,6 +34,8 @@ interests:
   - Systems biology
   - Image analysis
   - Microfluidics
+  - Microscopy
+  - F-techniques
   - 3D printing
 
 # Education to show in About widget

content/project/Microglia-project/index.md

@@ -0,0 +1,15 @@
+---
+title: Microglia role in brain repair
+summary: Investigating how mechanical forces exerted by microglia allow brain tissue recover its integrity after an injury
+tags:
+  - Regeneration
+  - Tissue repair
+  - Traumatic brain injury
+  - Zebrafish
+date: "2016-04-27T00:00:00Z"
+
+
+image:
+  caption: Microglia (green) invading the brain (neurons in red) of a zebrafish larva after injury
+  focal_point: Smart
+---

content/project/example/index.md → content/project/Stress-response/index.md

@@ -1,6 +1,6 @@
 ---
 title: Stress response in yeast
-summary: Investigaing how yeast cell cope with stress in various conditions
+summary: Investigating how yeast cell cope with stress in various conditions
 tags:
   - Stress response
   - Deep learning
@@ -12,7 +12,7 @@ date: '2016-04-27T00:00:00Z'
 external_link: ''
 
 image:
-  caption: Photo by rawpixel on Unsplash
+  caption: URA8 protein aggregation after glucose deprivation
   focal_point: Smart
 
 links:

content/publication/Microglia_TBI/cite.bib

@@ -0,0 +1,12 @@
+@article {El-Daher2024.06.04.597300,
+	author = {El-Daher, Francois and Drake, Louisa K. and Enos, Stephen J. and Wehner, Daniel and Westphal, Markus and Porter, Nicola J. and Becker, Catherina G. and Becker, Thomas},
+	title = {Wound closure after brain injury relies on force generation by microglia in zebrafish},
+	elocation-id = {2024.06.04.597300},
+	year = {2024},
+	doi = {10.1101/2024.06.04.597300},
+	publisher = {Cold Spring Harbor Laboratory},
+	abstract = {Wound closure after a brain injury is critical for tissue restoration but this process is still not well characterized at the tissue level. We use live observation of wound closure in larval zebrafish after inflicting a stab wound to the brain. We demonstrate that the wound closes in the first 24 hours after injury by global tissue contraction. Microglia accumulation at the point of tissue convergence precedes wound closure and computational modelling of this process indicates that physical traction by microglia could lead to wound closure. Indeed, genetically or pharmacologically depleting microglia leads to defective tissue repair. Live observations indicate centripetal deformation of astrocytic processes contacted by migrating microglia. Severing such contacts leads to retraction of cellular processes, indicating tension. Weakening tension by disrupting the F-actin stabilising gene lcp1 in microglial cells, leads to failure of wound closure. Therefore, we propose a previously unidentified mechanism of brain repair in which microglia has an essential role in contracting spared tissue. Understanding the mechanical role of microglia will support advances in traumatic brain injury therapiesCompeting Interest StatementThe authors have declared no competing interest.},
+	URL = {https://www.biorxiv.org/content/early/2024/06/13/2024.06.04.597300},
+	eprint = {https://www.biorxiv.org/content/early/2024/06/13/2024.06.04.597300.full.pdf},
+	journal = {bioRxiv}
+}

content/publication/Microglia_TBI/index.md

@@ -0,0 +1,18 @@
+---
+title: 'Wound closure after brain injury relies on force generation by microglia in zebrafish'
+authors:
+- F El-Daher
+- L K Drake
+- S J Enos
+- D Wehner
+- M Westphal
+- N J Porter
+- C G Becker
+- T Becker
+date: '2024-06-04'
+publishDate: '2024-05-03T13:16:53.416145Z'
+publication_types:
+- article-journal
+publication: '*bioRxiv*'
+doi: 10.1101/2024.06.04.597300
+---