The horticultural fungicide pyrifenox was tested against eumycetoma causing fungi as part of the same screen that marked fenarimol as a possible antifungal drug lead
This project aims to produce optimized analogues of pyrifenox for possible use against invasive fungal infections in humans
Pyrifenox and fenarimol share the same enzymatic target (CYP51F) as posaconazole and itraconazole‡ - the current gold standard drugs for eumycetoma treatment
‡ as per the Fungicide Resistance Action Committee
Compounds are currently being made by Dmitrij Melechov at UCL - You can click here to see his ELN