Object-oriented implementation of the NVU model and code.
Master branch: NVU 1.2
Contains the following components that were not present in NVU 1.1:
- Extracellular space compartment
- Astrocytic calcium pathway with EETs
- TRPV4 channel on the astrocytic endfoot
- Nitric oxide pathway
The code is run in Matlab:
- To solve the system use the script nvu_run_script.m
- To quickly plot all variables use the script plot_all_variables.m
Courtesy of the research group at University of Canterbury lead by Tim David. Majority of credit goes to: Allanah Kenny, Dr Katharina Dormanns
For further information on the model refer to the following papers:
Farr, H., & David, T. (2011). Models of neurovascular coupling via potassium and EET signalling. Journal of Theoretical Biology, 286(1), 13–23. http://doi.org/10.1016/j.jtbi.2011.07.006
Dormanns, K., van Disseldorp, E. M. J., Brown, R. G., & David, T. (2015). Neurovascular coupling and the influence of luminal agonists via the endothelium. Journal of Theoretical Biology, 364, 49–70. http://doi.org/10.1016/j.jtbi.2014.08.029
Dormanns, K., Brown, R. G. G., & David, T. (2016). The role of nitric oxide in neurovascular coupling. Journal of Theoretical Biology, 394, 1–17. http://doi.org/10.1016/j.jtbi.2016.01.009