GitHub - ModelDBRepository/151945: Electrodiffusive astrocytic and extracellular ion concentration dynamics model (Halnes et al. 2013)

ModelDBRepository / 151945 Public

Notifications You must be signed in to change notification settings
Fork 1
Star 0

Electrodiffusive astrocytic and extracellular ion concentration dynamics model (Halnes et al. 2013)

modeldb.science/151945

Notifications

Name		Name	Last commit message	Last commit date
Latest commit History 1 Commit
Kirf.m		Kirf.m
NaKpumprate.m		NaKpumprate.m
PlotK.m		PlotK.m
Readme.html		Readme.html
eldiff.m		eldiff.m
mosinit.m		mosinit.m
plotarticle.m		plotarticle.m
screenshot1.png		screenshot1.png
screenshot2.png		screenshot2.png
screenshot3.png		screenshot3.png

Repository files navigation

<html><pre>
Matlab files for the model used in the paper:

Halnes G., Ostby, I., Pettersen, KH., Omholt, S. & Einevoll, GT. (2013)
Electrodiffusive model for astrocytic and neuronal ion concentration dynamics.
PLoS Comp. Biol. 9(12): e1003386

In Halnes et al. 2013, an electrodiffusive formalism was developed for
computing the dynamics of the membrane potential and ion
concentrations in the intra- and extracellular space in a
one-dimensional geometry (cable). This (general) formalism was
implemented in a model of astrocytes exchanging K+, Na+ and Cl- ions
with the extracellular space (ECS).  In a limited region (0&lt;x&lt;l/10
where l is the astrocyte length), the ECS was exposed to an increase
in the local K+ concentration. Simulations were run to explore how the
astrocyte contributed in transporting K+ out from the
high-concentration region via a mechanism known as spatial buffering,
which involves local uptake from high concentration regions,
intracellular transport, and release of K+ in regions with lower ECS
concentrations.

The Matlab-files represent the astrocyte/ECS model, and reproduce
three of the figures (figures 4, 5 and 6) from Halnes et
al. 2013. Note the matlab titlebar figure numbers are different than
the paper figure numbers:

Figure 4:
<img src="./screenshot1.png" alt="screenshot 1">

Figure 5:
<img src="./screenshot2.png" alt="screenshot 2">

Figure 6:
<img src="./screenshot3.png" alt="screenshot 3">

We refer to the paper for more details.

The model files were supplied by Geir Halnes
</pre></html>