diff --git a/.github/workflows/tests.yml b/.github/workflows/tests.yml
index ace8f74..c46c68e 100644
--- a/.github/workflows/tests.yml
+++ b/.github/workflows/tests.yml
@@ -102,7 +102,7 @@ jobs:
           - "3.9"
           - "3.10"
           - "3.11"
-          - "3.12.0-alpha.6"
+          - "3.12.0-beta.4"
         os: [ubuntu-20.04, macos-11]
         exclude:
           - os: macos-11
@@ -178,15 +178,15 @@ jobs:
           python setup.py build_ext -i
           python setup.py bdist_wheel
 
-      - name: Install persistent and dependencies (3.12.0-alpha.6)
-        if: matrix.python-version == '3.12.0-alpha.6'
+      - name: Install persistent and dependencies (3.12.0-beta.4)
+        if: matrix.python-version == '3.12.0-beta.4'
         run: |
           # Install to collect dependencies into the (pip) cache.
           # Use "--pre" here because dependencies with support for this future
           # Python release may only be available as pre-releases
           pip install --pre .[test]
       - name: Install persistent and dependencies
-        if: matrix.python-version != '3.12.0-alpha.6'
+        if: matrix.python-version != '3.12.0-beta.4'
         run: |
           # Install to collect dependencies into the (pip) cache.
           pip install .[test]
@@ -230,7 +230,7 @@ jobs:
           && startsWith(github.ref, 'refs/tags')
           && startsWith(runner.os, 'Mac')
           && !startsWith(matrix.python-version, 'pypy')
-          && !startsWith(matrix.python-version, '3.12.0-alpha.6')
+          && !startsWith(matrix.python-version, '3.12.0-beta.4')
         env:
           TWINE_PASSWORD: ${{ secrets.TWINE_PASSWORD }}
         run: |
@@ -249,7 +249,7 @@ jobs:
           - "3.9"
           - "3.10"
           - "3.11"
-          - "3.12.0-alpha.6"
+          - "3.12.0-beta.4"
         os: [ubuntu-20.04, macos-11]
         exclude:
           - os: macos-11
@@ -286,8 +286,8 @@ jobs:
         with:
           name: persistent-${{ runner.os }}-${{ matrix.python-version }}.whl
           path: dist/
-      - name: Install persistent 3.12.0-alpha.6
-        if: ${{ startsWith(matrix.python-version, '3.12.0-alpha.6') }}
+      - name: Install persistent 3.12.0-beta.4
+        if: ${{ startsWith(matrix.python-version, '3.12.0-beta.4') }}
         run: |
           pip install -U wheel setuptools
           # coverage has a wheel on PyPI for a future python version which is
@@ -301,7 +301,7 @@ jobs:
           # Python release may only be available as pre-releases
           pip install --pre -U -e .[test]
       - name: Install persistent
-        if: ${{ !startsWith(matrix.python-version, '3.12.0-alpha.6') }}
+        if: ${{ !startsWith(matrix.python-version, '3.12.0-beta.4') }}
         run: |
           pip install -U wheel setuptools
           pip install -U coverage
diff --git a/.meta.toml b/.meta.toml
index 3342e71..e6126af 100644
--- a/.meta.toml
+++ b/.meta.toml
@@ -2,7 +2,7 @@
 # https://github.com/zopefoundation/meta/tree/master/config/c-code
 [meta]
 template = "c-code"
-commit-id = "dec712c6"
+commit-id = "b99ba750"
 
 [python]
 with-appveyor = true
diff --git a/CHANGES.rst b/CHANGES.rst
index 1a54031..fb12e3b 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -5,7 +5,7 @@
 5.1 (unreleased)
 ================
 
-- Add preliminary support for Python 3.12a6.
+- Add preliminary support for Python 3.12b4.
 
 
 5.0 (2023-01-09)
diff --git a/tox.ini b/tox.ini
index f56b26b..b310d28 100644
--- a/tox.ini
+++ b/tox.ini
@@ -22,6 +22,8 @@ deps =
 setenv =
     pure: PURE_PYTHON=1
     !pure-!pypy3: PURE_PYTHON=0
+    py312: VIRTUALENV_PIP=23.1.2
+    py312: PIP_REQUIRE_VIRTUALENV=0
 commands =
     zope-testrunner --test-path=src {posargs:-vc}
     sphinx-build -b doctest -d {envdir}/.cache/doctrees docs {envdir}/.cache/doctest