diff --git a/packages/powersync-sdk-react-native/package.json b/packages/powersync-sdk-react-native/package.json
index 02abac1c..61ffe8bf 100644
--- a/packages/powersync-sdk-react-native/package.json
+++ b/packages/powersync-sdk-react-native/package.json
@@ -24,7 +24,7 @@
   },
   "homepage": "https://docs.powersync.co/",
   "peerDependencies": {
-    "@journeyapps/react-native-quick-sqlite": "^0.0.1",
+    "@journeyapps/react-native-quick-sqlite": "0.0.0-dev-20231023173642",
     "base-64": "^1.0.0",
     "react": "*",
     "react-native-fetch-api": "^3.0.0",
@@ -40,7 +40,7 @@
     "async-lock": "^1.4.0"
   },
   "devDependencies": {
-    "@journeyapps/react-native-quick-sqlite": "^0.0.1",
+    "@journeyapps/react-native-quick-sqlite": "0.0.0-dev-20231023173642",
     "@types/async-lock": "^1.4.0",
     "react": "18.2.0",
     "typescript": "^4.1.3"
diff --git a/packages/powersync-sdk-react-native/src/db/adapters/react-native-quick-sqlite/RNQSDBOpenFactory.ts b/packages/powersync-sdk-react-native/src/db/adapters/react-native-quick-sqlite/RNQSDBOpenFactory.ts
index bb8112da..c44530be 100644
--- a/packages/powersync-sdk-react-native/src/db/adapters/react-native-quick-sqlite/RNQSDBOpenFactory.ts
+++ b/packages/powersync-sdk-react-native/src/db/adapters/react-native-quick-sqlite/RNQSDBOpenFactory.ts
@@ -1,4 +1,4 @@
-import { open } from '@journeyapps/react-native-quick-sqlite';
+import { open, QuickSQLite, QuickSQLiteConnection } from '@journeyapps/react-native-quick-sqlite';
 
 import {
   AbstractPowerSyncDatabase,
@@ -19,7 +19,22 @@ export class RNQSPowerSyncDatabaseOpenFactory extends AbstractPowerSyncDatabaseO
      * in the options (if provided)
      * https://github.com/margelo/react-native-quick-sqlite/blob/main/README.md#loading-existing-dbs
      */
-    return new RNQSDBAdapter(open(this.options.dbFilename, { location: this.options.dbLocation }));
+    const { dbFilename } = this.options;
+    const openOptions = { location: this.options.dbLocation };
+    let DB: QuickSQLiteConnection;
+    try {
+      // Hot reloads can sometimes clear global JS state, but not close DB on native side
+      DB = open(dbFilename, openOptions);
+    } catch (ex) {
+      if (ex.message.includes('already open')) {
+        QuickSQLite.close(dbFilename);
+        DB = open(dbFilename, openOptions);
+      } else {
+        throw ex;
+      }
+    }
+
+    return new RNQSDBAdapter(DB);
   }
 
   generateInstance(options: PowerSyncDatabaseOptions): AbstractPowerSyncDatabase {
diff --git a/yarn.lock b/yarn.lock
index d552a964..1ece8051 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -2134,10 +2134,12 @@
     "@types/yargs" "^17.0.8"
     chalk "^4.0.0"
 
-"@journeyapps/react-native-quick-sqlite@0.0.1", "@journeyapps/react-native-quick-sqlite@^0.0.1":
-  version "0.0.1"
-  resolved "https://registry.npmjs.org/@journeyapps/react-native-quick-sqlite/-/react-native-quick-sqlite-0.0.1.tgz#a5b731bfc658d6c8257ef3edebf243941a69a764"
-  integrity sha512-vUXWngjpTFX6xCsy6Y8jd9zcI1eajIw/rWfdkpJOdnazR0SzAmrMc0ViRB6K84fWq9CmAV3DZw+GCVEHubqhSw==
+"@journeyapps/react-native-quick-sqlite@0.0.0-dev-20231023173642":
+  version "0.0.0-dev-20231023173642"
+  resolved "https://registry.npmjs.org/@journeyapps/react-native-quick-sqlite/-/react-native-quick-sqlite-0.0.0-dev-20231023173642.tgz#00cfd6aec9674519ffbbc06245e7ce4ce42a0bcb"
+  integrity sha512-Na4XDi2u5AUZw+/mflV6LLIHJJvfvJxp5uYMDZtG+4WZ4dw0NDq+sZk+U26T/IU9xgdDWlcmwVKku9dDHLt7eg==
+  dependencies:
+    lodash "^4.17.21"
 
 "@jridgewell/gen-mapping@^0.3.0", "@jridgewell/gen-mapping@^0.3.2":
   version "0.3.3"