diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index ea15e135455ba..6ab940efaddd4 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -35,25 +35,15 @@ repos:
         # we can lint all header files since they aren't "generated" like C files are.
         exclude: ^pandas/_libs/src/(klib|headers)/
         args: [--quiet, '--extensions=c,h', '--headers=h', --recursive, '--filter=-readability/casting,-runtime/int,-build/include_subdir']
--   repo: https://gitlab.com/pycqa/flake8
-    rev: 3.9.2
+-   repo: https://github.com/PyCQA/flake8
+    rev: 4.0.1
     hooks:
     -   id: flake8
         additional_dependencies: &flake8_dependencies
-        - flake8==3.9.2
-        - flake8-comprehensions==3.1.0
+        - flake8==4.0.1
+        - flake8-comprehensions==3.7.0
         - flake8-bugbear==21.3.2
         - pandas-dev-flaker==0.2.0
-    -   id: flake8
-        alias: flake8-cython
-        name: flake8 (cython)
-        types: [cython]
-        args: [--append-config=flake8/cython.cfg]
-    -   id: flake8
-        name: flake8 (cython template)
-        files: \.pxi\.in$
-        types: [text]
-        args: [--append-config=flake8/cython-template.cfg]
 -   repo: https://github.com/PyCQA/isort
     rev: 5.10.1
     hooks:
diff --git a/environment.yml b/environment.yml
index 0e303d1fa7da2..ef6ec7352db05 100644
--- a/environment.yml
+++ b/environment.yml
@@ -20,9 +20,9 @@ dependencies:
   # code checks
   - black=21.5b2
   - cpplint
-  - flake8=3.9.2
+  - flake8=4.0.1
   - flake8-bugbear=21.3.2  # used by flake8, find likely bugs
-  - flake8-comprehensions=3.1.0  # used by flake8, linting of unnecessary comprehensions
+  - flake8-comprehensions=3.7.0  # used by flake8, linting of unnecessary comprehensions
   - isort>=5.2.1  # check that imports are in the right order
   - mypy=0.920
   - pre-commit>=2.9.2
diff --git a/flake8/cython-template.cfg b/flake8/cython-template.cfg
deleted file mode 100644
index 3d7b288fd8055..0000000000000
--- a/flake8/cython-template.cfg
+++ /dev/null
@@ -1,3 +0,0 @@
-[flake8]
-filename = *.pxi.in
-select = E501,E302,E203,E111,E114,E221,E303,E231,E126,F403
diff --git a/flake8/cython.cfg b/flake8/cython.cfg
deleted file mode 100644
index bf1f41647b34e..0000000000000
--- a/flake8/cython.cfg
+++ /dev/null
@@ -1,13 +0,0 @@
-[flake8]
-filename = *.pyx,*.pxd
-extend_ignore=
-    # whitespace before '('
-    E211,
-    # missing whitespace around operator
-    E225,
-    # missing whitespace around arithmetic operator
-    E226,
-    # missing whitespace around bitwise or shift operator
-    E227,
-    # invalid syntax
-    E999,
diff --git a/requirements-dev.txt b/requirements-dev.txt
index a7bdc972fb203..2f80440e71d16 100644
--- a/requirements-dev.txt
+++ b/requirements-dev.txt
@@ -8,9 +8,9 @@ asv
 cython>=0.29.24
 black==21.5b2
 cpplint
-flake8==3.9.2
+flake8==4.0.1
 flake8-bugbear==21.3.2
-flake8-comprehensions==3.1.0
+flake8-comprehensions==3.7.0
 isort>=5.2.1
 mypy==0.920
 pre-commit>=2.9.2