Is an RNA modality file from multiome needed/necessary to annotate clusters in scATAC dataset?

[yojetsharma]

The tutorial mentions use of a RNA multiome file[(reference = snap.read(snap.datasets.pbmc10k_multiome(), backed=None)] for annotation of clusters in scATAC dataset (https://kzhang.org/SnapATAC2/tutorials/annotation.html).

[kaizhang]

This is not necessary. You can annotate the cells based on marker genes' activity.

[yojetsharma]

Is there a tutorial for how to do that? I am new to this so still trying to my find my footing.
How can I just my scRNA seq to annotate the scATAC clusters?

[kaizhang]

What data do you have, scATAC or single-cell multiome dataset?

[yojetsharma]

I have a single-cell multiome dataset from multiple samples that I want to process as concatenated/merged anndata object.