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Add PEAR for merging overlapping paired-end reads #378

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iskandr opened this issue Oct 26, 2016 · 2 comments
Open

Add PEAR for merging overlapping paired-end reads #378

iskandr opened this issue Oct 26, 2016 · 2 comments

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@iskandr
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iskandr commented Oct 26, 2016

http://sco.h-its.org/exelixis/web/software/pear/doc.html

@JPFinnigan
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Apologies if you have already implemented MaSuRCA, but this utility and PEAR seemingly performs a similar function, but MaSuRCA can also be utilized for the "super-read" assembly workflow in StringTie. Link: http://www.genome.umd.edu/masurca.html

Not sure which of two, PEAR or MaSuRCA, will be most useful to you guys going forward.

@iskandr
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iskandr commented Oct 27, 2016

It seems like MaSuRCA is much heavier weight since it actually does genome assembly, whereas PEAR will just merge paired reads which seem to overlap due to insufficient fragment/insert size.

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