diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 97bd292..71d3072 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -30,6 +30,7 @@ jobs:
       - run: cargo test --features=prometheus-exporter,prometheus-0_13
       - run: cargo test --features=prometheus-exporter,prometheus-client-0_21,exemplars-tracing
       - run: cargo test --features=prometheus-exporter,prometheus-client-0_21,exemplars-tracing-opentelemetry-0_20
+      - run: cargo test --features=prometheus-exporter,prometheus-client-0_21,exemplars-tracing-opentelemetry-0_21
       - run: cargo test --features=prometheus-exporter,opentelemetry-0_20
 
       # Build the crate using the other optional features
diff --git a/autometrics/Cargo.toml b/autometrics/Cargo.toml
index 408b40a..db32c9a 100644
--- a/autometrics/Cargo.toml
+++ b/autometrics/Cargo.toml
@@ -73,7 +73,12 @@ exemplars-tracing = ["tracing", "tracing-subscriber"]
 exemplars-tracing-opentelemetry-0_20 = [
   "opentelemetry_api/trace",
   "tracing",
-  "tracing-opentelemetry",
+  "dep:tracing-opentelemetry-0-20",
+]
+exemplars-tracing-opentelemetry-0_21 = [
+  "opentelemetry_api/trace",
+  "tracing",
+  "dep:tracing-opentelemetry-0-21",
 ]
 
 # Custom objectives
@@ -113,7 +118,8 @@ tracing-subscriber = { version = "0.3", default-features = false, features = [
 ], optional = true }
 
 # Used for exemplars-tracing-opentelemetry feature
-tracing-opentelemetry = { version = "0.20", default-features = false, optional = true }
+tracing-opentelemetry-0-20 = { package = "tracing-opentelemetry", version = "0.20.0", default-features = false, optional = true }
+tracing-opentelemetry-0-21 = { package = "tracing-opentelemetry", version = "0.21.0", default-features = false, optional = true }
 
 [dev-dependencies]
 axum = { version = "0.6", features = ["tokio"] }
@@ -124,7 +130,6 @@ opentelemetry-stdout = { version = "0.1", features = ["trace"] }
 prometheus-client = "0.21"
 tokio = { version = "1", features = ["full"] }
 tracing = "0.1"
-tracing-opentelemetry = "0.20"
 tracing-subscriber = "0.3"
 trybuild = "1.0"
 uuid = { version = "1", features = ["v4"] }
diff --git a/autometrics/build.rs b/autometrics/build.rs
index 9917a0b..17ae3d0 100644
--- a/autometrics/build.rs
+++ b/autometrics/build.rs
@@ -12,7 +12,7 @@ pub fn main() {
     #[cfg(feature = "prometheus-client")]
     println!("cargo:warning=The `prometheus-client` feature is deprecated and will be removed in the next version. Please use `prometheus-client-0_21` instead.");
     #[cfg(feature = "exemplars-tracing-opentelemetry")]
-    println!("cargo:warning=The `exemplars-tracing-opentelemetry` feature is deprecated and will be removed in the next version. Please use `exemplars-tracing-opentelemetry-0_20` instead.");
+    println!("cargo:warning=The `exemplars-tracing-opentelemetry` feature is deprecated and will be removed in the next version. Please use `exemplars-tracing-opentelemetry-0_20` or `exemplars-tracing-opentelemetry-0_21` instead.");
 
     cfg_aliases! {
       // Backends
@@ -32,7 +32,7 @@ pub fn main() {
       // Exemplars
       exemplars: { any(exemplars_tracing, exemplars_tracing_opentelemetry) },
       exemplars_tracing: { feature = "exemplars-tracing" },
-      exemplars_tracing_opentelemetry: { any(feature = "exemplars-tracing-opentelemetry-0_20", feature = "exemplars-tracing-opentelemetry") },
+      exemplars_tracing_opentelemetry: { any(feature = "exemplars-tracing-opentelemetry-0_20", feature = "exemplars-tracing-opentelemetry-0_21", feature = "exemplars-tracing-opentelemetry") },
 
       // Custom objectives
       custom_objective_percentile: { feature = "custom-objective-percentile" },
diff --git a/autometrics/src/README.md b/autometrics/src/README.md
index d163d0c..fb72294 100644
--- a/autometrics/src/README.md
+++ b/autometrics/src/README.md
@@ -158,7 +158,7 @@ If you require more customization than these offered feature flags, enable just
 See the [exemplars module docs](https://docs.rs/autometrics/latest/autometrics/exemplars/index.html) for details about these features. Currently only supported with the `prometheus-client` backend.
 
 - `exemplars-tracing` - extract arbitrary fields from `tracing::Span`s
-- `exemplars-tracing-opentelemetry-0_20` - extract the `trace_id` and `span_id` from the `opentelemetry::Context`, which is attached to `tracing::Span`s by the `tracing-opentelemetry` crate
+- `exemplars-tracing-opentelemetry-0_20` or `exemplars-tracing-opentelemetry-0_21` - extract the `trace_id` and `span_id` from the `opentelemetry::Context`, which is attached to `tracing::Span`s by the `tracing-opentelemetry` crate
 
 ### Custom objective values
 
diff --git a/autometrics/src/exemplars/tracing_opentelemetry.rs b/autometrics/src/exemplars/tracing_opentelemetry.rs
index 07ca105..9e7b314 100644
--- a/autometrics/src/exemplars/tracing_opentelemetry.rs
+++ b/autometrics/src/exemplars/tracing_opentelemetry.rs
@@ -2,11 +2,22 @@ use super::TraceLabels;
 use opentelemetry_api::trace::TraceContextExt;
 use std::iter::FromIterator;
 use tracing::Span;
-use tracing_opentelemetry::OpenTelemetrySpanExt;
+
+#[cfg(all(
+    not(doc),
+    all(
+        feature = "exemplars-tracing-opentelemetry-0_20",
+        feature = "exemplars-tracing-opentelemetry-0_21"
+    )
+))]
+compile_error!("Only one of the `exemplars-tracing-opentelemetry-0_20` and `exemplars-tracing-opentelemetry-0_21` features can be enabled at a time");
 
 pub fn get_exemplar() -> Option<TraceLabels> {
     // Get the OpenTelemetry Context from the tracing span
-    let context = Span::current().context();
+    #[cfg(feature = "exemplars-tracing-opentelemetry-0_20")]
+    let context = tracing_opentelemetry_0_20::OpenTelemetrySpanExt::context(&Span::current());
+    #[cfg(feature = "exemplars-tracing-opentelemetry-0_21")]
+    let context = tracing_opentelemetry_0_21::OpenTelemetrySpanExt::context(&Span::current());
 
     // Now get the OpenTelemetry "span" from the Context
     // (it's confusing because the word "span" is used by both tracing and OpenTelemetry
diff --git a/autometrics/src/lib.rs b/autometrics/src/lib.rs
index 46261c2..12623af 100644
--- a/autometrics/src/lib.rs
+++ b/autometrics/src/lib.rs
@@ -10,6 +10,7 @@ mod constants;
     feature = "exemplars-tracing",
     feature = "exemplars-tracing-opentelemetry",
     feature = "exemplars-tracing-opentelemetry-0_20",
+    feature = "exemplars-tracing-opentelemetry-0_21",
 ))]
 pub mod exemplars;
 mod labels;
diff --git a/autometrics/tests/exemplars_test.rs b/autometrics/tests/exemplars_test.rs
index 655f7fe..a32e5b1 100644
--- a/autometrics/tests/exemplars_test.rs
+++ b/autometrics/tests/exemplars_test.rs
@@ -70,7 +70,10 @@ fn tracing_opentelemetry_context() {
     let tracer = provider.tracer("test");
 
     // This adds the OpenTelemetry Context to every tracing Span
-    let otel_layer = tracing_opentelemetry::layer().with_tracer(tracer);
+    #[cfg(feature = "exemplars-tracing-opentelemetry-0_20")]
+    let otel_layer = tracing_opentelemetry_0_20::layer().with_tracer(tracer);
+    #[cfg(feature = "exemplars-tracing-opentelemetry-0_21")]
+    let otel_layer = tracing_opentelemetry_0_21::layer().with_tracer(tracer);
     let subscriber = Registry::default().with(otel_layer);
 
     #[autometrics]
diff --git a/examples/exemplars-tracing-opentelemetry/Cargo.toml b/examples/exemplars-tracing-opentelemetry/Cargo.toml
index e6292be..369fd8b 100644
--- a/examples/exemplars-tracing-opentelemetry/Cargo.toml
+++ b/examples/exemplars-tracing-opentelemetry/Cargo.toml
@@ -8,7 +8,7 @@ edition = "2021"
 autometrics = { path = "../../autometrics", features = [
   "prometheus-client-0_21",
   "prometheus-exporter",
-  "exemplars-tracing-opentelemetry-0_20",
+  "exemplars-tracing-opentelemetry-0_21",
 ] }
 autometrics-example-util = { path = "../util" }
 axum = { version = "0.6", features = ["json"] }
@@ -17,5 +17,5 @@ opentelemetry-stdout = { version = "0.1", features = ["trace"] }
 reqwest = { version = "0.11", features = ["json"] }
 tokio = { version = "1", features = ["full"] }
 tracing = "0.1"
-tracing-opentelemetry = "0.20"
+tracing-opentelemetry = "0.21"
 tracing-subscriber = { version = "0.3", features = ["env-filter"] }