diff --git a/.github/workflows/wheels.yml b/.github/workflows/wheels.yml
index df9191b0807..6e69e01af66 100644
--- a/.github/workflows/wheels.yml
+++ b/.github/workflows/wheels.yml
@@ -30,7 +30,7 @@ jobs:
         with:
           components: llvm-tools-preview
       - name: Build wheels
-        uses: pypa/cibuildwheel@v2.19.2
+        uses: pypa/cibuildwheel@v2.21.1
         env:
           CIBW_BEFORE_BUILD: 'bash ./tools/build_pgo.sh /tmp/pgo-data/merged.profdata'
           CIBW_BEFORE_BUILD_WINDOWS: 'bash ./tools/build_pgo.sh /tmp/pgo-data/merged.profdata && cp /tmp/pgo-data/merged.profdata ~/.'
@@ -58,7 +58,7 @@ jobs:
         with:
           components: llvm-tools-preview
       - name: Build wheels
-        uses: pypa/cibuildwheel@v2.19.2
+        uses: pypa/cibuildwheel@v2.21.1
         env:
           CIBW_SKIP: 'pp* cp36-* cp37-* cp38-* *musllinux* *amd64 *x86_64'
       - uses: actions/upload-artifact@v4
@@ -104,7 +104,7 @@ jobs:
         with:
           platforms: all
       - name: Build wheels
-        uses: pypa/cibuildwheel@v2.19.2
+        uses: pypa/cibuildwheel@v2.21.1
         env:
           CIBW_ARCHS_LINUX: s390x
           CIBW_TEST_SKIP: "cp*"
@@ -138,7 +138,7 @@ jobs:
         with:
           platforms: all
       - name: Build wheels
-        uses: pypa/cibuildwheel@v2.19.2
+        uses: pypa/cibuildwheel@v2.21.1
         env:
           CIBW_ARCHS_LINUX: ppc64le
           CIBW_TEST_SKIP: "cp*"
@@ -172,7 +172,7 @@ jobs:
         with:
           platforms: all
       - name: Build wheels
-        uses: pypa/cibuildwheel@v2.19.2
+        uses: pypa/cibuildwheel@v2.21.1
         env:
           CIBW_ARCHS_LINUX: aarch64
           CIBW_TEST_COMMAND: cp -r {project}/test . && QISKIT_PARALLEL=FALSE stestr --test-path test/python run --abbreviate -n test.python.compiler.test_transpiler