diff --git a/CHANGELOG.md b/CHANGELOG.md
index dd7bb35e2c9..443357129ea 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,8 @@
 
 ## [Unreleased]
 
+- Add a global Axis/Axis3D registry for default interactions [#4531](https://github.com/MakieOrg/Makie.jl/pull/4531).
+
 ## [0.21.15] - 2024-10-25
 
 - Allowed creation of `Legend` with entries that have no legend elements [#4526](https://github.com/MakieOrg/Makie.jl/pull/4526).
diff --git a/src/interaction/events.jl b/src/interaction/events.jl
index 20e10ce29a6..c1f9f383e4d 100644
--- a/src/interaction/events.jl
+++ b/src/interaction/events.jl
@@ -288,6 +288,7 @@ See also: [`And`](@ref), [`Or`](@ref), [`Not`](@ref), [`Exclusively`](@ref),
 ispressed(events::Events, mb::Mouse.Button, waspressed = nothing) = mb in events.mousebuttonstate || mb == waspressed
 ispressed(events::Events, key::Keyboard.Button, waspressed = nothing) = key in events.keyboardstate || key == waspressed
 ispressed(parent, result::Bool, waspressed = nothing) = result
+ispressed(parent, result::Nothing, waspressed = nothing) = true
 
 ispressed(parent, mb::Mouse.Button, waspressed = nothing) = ispressed(events(parent), mb, waspressed)
 ispressed(parent, key::Keyboard.Button, waspressed = nothing) = ispressed(events(parent), key, waspressed)
diff --git a/src/makielayout/blocks/axis.jl b/src/makielayout/blocks/axis.jl
index 0213500642e..8b532adb832 100644
--- a/src/makielayout/blocks/axis.jl
+++ b/src/makielayout/blocks/axis.jl
@@ -1,3 +1,10 @@
+const DEFAULT_AXIS_INTERACTIONS = Dict(
+    :rectanglezoom => () -> RectangleZoom(),
+    :limitreset => () -> LimitReset(),
+    :scrollzoom => () -> ScrollZoom(0.1, 0.2),
+    :dragpan => () -> DragPan(0.2),
+)
+
 function update_gridlines!(grid_obs::Observable{Vector{Point2f}}, offset::Point2f, tickpositions::Vector{Point2f})
     result = grid_obs[]
     empty!(result) # reuse array for less allocations
@@ -49,13 +56,9 @@ function register_events!(ax, scene)
     onany(process_axis_event, scene, ax, scrollevents)
     onany(process_axis_event, scene, ax, keysevents)
 
-    register_interaction!(ax, :rectanglezoom, RectangleZoom(ax))
-
-    register_interaction!(ax, :limitreset, LimitReset())
-
-    register_interaction!(ax, :scrollzoom, ScrollZoom(0.1, 0.2))
-
-    register_interaction!(ax, :dragpan, DragPan(0.2))
+    for (name, fn) in DEFAULT_AXIS_INTERACTIONS
+        register_interaction!(ax, name, fn())
+    end
 
     return
 end
diff --git a/src/makielayout/blocks/axis3d.jl b/src/makielayout/blocks/axis3d.jl
index a6b97462925..5fa57e95b22 100644
--- a/src/makielayout/blocks/axis3d.jl
+++ b/src/makielayout/blocks/axis3d.jl
@@ -1,3 +1,7 @@
+const DEFAULT_AXIS_3D_INTERACTIONS = Dict(
+    :dragrotate => () -> DragRotate(),
+)
+
 struct OrthographicCamera <: AbstractCamera end
 
 function initialize_block!(ax::Axis3)
@@ -158,10 +162,9 @@ function initialize_block!(ax::Axis3)
     on(process_event, scene, ax.scrollevents)
     on(process_event, scene, ax.keysevents)
 
-    register_interaction!(ax,
-        :dragrotate,
-        DragRotate())
-
+    for (name, fn) in DEFAULT_AXIS_3D_INTERACTIONS
+        register_interaction!(ax, name, fn())
+    end
 
     # in case the user set limits already
     notify(ax.limits)
diff --git a/src/makielayout/interactions.jl b/src/makielayout/interactions.jl
index 5d75285b5d3..016653b8775 100644
--- a/src/makielayout/interactions.jl
+++ b/src/makielayout/interactions.jl
@@ -54,11 +54,11 @@ function deregister_interaction!(parent, name::Symbol)
 end
 
 function registration_setup!(parent, interaction)
-    # do nothing in the default case
+    return parent # do nothing in the default case
 end
 
 function deregistration_cleanup!(parent, interaction)
-    # do nothing in the default case
+    return parent # do nothing in the default case
 end
 
 """
@@ -177,10 +177,9 @@ function process_interaction(r::RectangleZoom, event::MouseEvent, ax::Axis)
         return Consume(true)
 
     elseif event.type === MouseEventTypes.leftdragstop
-        try
-            r.callback(r.rectnode[])
-        catch e
-            @warn "error in rectangle zoom" exception=(e, Base.catch_backtrace())
+        newlims = r.rectnode[]
+        if !(0 in widths(newlims))
+            ax.targetlimits[] = newlims
         end
         r.active[] = false
         return Consume(true)
@@ -200,6 +199,12 @@ function process_interaction(r::RectangleZoom, event::KeysEvent, ax::Axis)
     r.restrict_x = Keyboard.y in event.keys
     r.active[] || return Consume(false)
 
+    # Deactivate when modifier is released before the mouse.
+    if r.modifier !== true && r.modifier ∉ event.keys
+        r.active[] = false
+        return Consume(true)
+    end
+
     r.rectnode[] = _chosen_limits(r, ax)
     return Consume(true)
 end
@@ -211,11 +216,11 @@ function positivize(r::Rect2)
     return Rect2(newori, newwidths)
 end
 
-function process_interaction(::LimitReset, event::MouseEvent, ax::Axis)
+function process_interaction(l::LimitReset, event::MouseEvent, ax::Axis)
 
-    if event.type === MouseEventTypes.leftclick
-        if ispressed(ax.scene, Keyboard.left_control)
-            if ispressed(ax.scene, Keyboard.left_shift)
+    if event.type === l.mouseevent
+        if ispressed(ax.scene, l.modifier1)
+            if ispressed(ax.scene, l.modifier2)
                 autolimits!(ax)
             else
                 reset_limits!(ax)
diff --git a/src/makielayout/types.jl b/src/makielayout/types.jl
index 4da455bf423..3f48f56667f 100644
--- a/src/makielayout/types.jl
+++ b/src/makielayout/types.jl
@@ -149,10 +149,22 @@ mutable struct LineAxis
     minortickvalues::Observable{Vector{Float32}}
 end
 
-struct LimitReset end
+
+struct LimitReset
+    mouseevent::MouseEventTypes.MouseEventType # e.g. MouseEventTypes.leftclick, or some other mouse event to start limit reset.
+    modifier1::Optional{Keyboard.Button} # e.g. Keyboard.left_control, or some other keyboard button to reset limits.
+    modifier2::Optional{Keyboard.Button} # e.g. Keyboard.left_shift, or some other keyboard button to auto limits.
+
+    function LimitReset(
+        mouseevent = MouseEventTypes.leftclick,
+        modifier1 = Keyboard.left_control,
+        modifier2 = Keyboard.left_shift,
+    )
+        new(mouseevent, modifier1, modifier2)
+    end
+end
 
 mutable struct RectangleZoom
-    callback::Function
     active::Observable{Bool}
     restrict_x::Bool
     restrict_y::Bool
@@ -162,8 +174,8 @@ mutable struct RectangleZoom
     modifier::Any # e.g. Keyboard.left_alt, or some other button that needs to be pressed to start rectangle... Defaults to `true`, which means no modifier needed
 end
 
-function RectangleZoom(callback::Function; restrict_x=false, restrict_y=false, modifier=true)
-    return RectangleZoom(callback, Observable(false), restrict_x, restrict_y,
+function RectangleZoom(restrict_x=false, restrict_y=false, modifier=true)
+    return RectangleZoom(Observable(false), restrict_x, restrict_y,
                          nothing, nothing, Observable(Rect2d(0, 0, 1, 1)), modifier)
 end
 
@@ -190,9 +202,8 @@ function DragPan(reset_delay)
     return DragPan(RefValue{Union{Nothing, Timer}}(nothing), RefValue{Union{Automatic, Float64}}(0.0), RefValue{Union{Automatic, Float64}}(0.0), reset_delay)
 end
 
+struct DragRotate end
 
-struct DragRotate
-end
 
 struct ScrollEvent
     x::Float32
@@ -679,8 +690,8 @@ Axis(fig_or_scene; palette = nothing, kwargs...)
     end
 end
 
-function RectangleZoom(f::Function, ax::Axis; kw...)
-    r = RectangleZoom(f; kw...)
+
+function registration_setup!(ax::Axis, r::RectangleZoom)
     rect_scene = Scene(ax.scene)
     selection_vertices = lift(_selection_vertices, rect_scene, Observable(ax.scene), ax.finallimits,
                               r.rectnode)
@@ -694,18 +705,16 @@ function RectangleZoom(f::Function, ax::Axis; kw...)
         inspectable = false, transparency=true, overdraw=true, visible=r.active)
     # translate forward so selection mesh and frame are never behind data
     translate!(mesh, 0, 0, 1000)
-    return r
+
+    return ax
 end
 
-function RectangleZoom(ax::Axis; kw...)
-    return RectangleZoom(ax; kw...) do newlims
-        if !(0 in widths(newlims))
-            ax.targetlimits[] = newlims
-        end
-        return
-    end
+function deregistration_cleanup!(ax::Axis, r::RectangleZoom)
+    # TODO: Remove mesh?
+    return ax
 end
 
+
 """
 Create a colorbar that shows a continuous or categorical colormap with ticks
 chosen according to the colorrange.