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"results": [ - { - "columns": [ - "r.text", - "n.text", - "n.startOffset", - "n.endOffset" - ], - "data": [ - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "BREAST", - 442, - 448 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "LEFT", - 450, - 454 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "2 O'CLOCK", - 456, - 465 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "BREAST", - 6719, - 6725 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "Right", - 6743, - 6748 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "Neoadjuvant Therapy", - 8102, - 8121 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "Neoadjuvant Therapy", - 8144, - 8163 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "DCIS", - 1106, - 1110 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "DCIS", - 775, - 779 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "DCIS", - 821, - 825 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "DUCTAL CARCINOMA IN SITU", - 749, - 773 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "pT1c", - 7625, - 7629 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "pN0", - 7684, - 7687 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "1.9 CM", - 713, - 719 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "PROGESTERONE RECEPTORS ", - 1313, - 1336 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "POSITIVE", - 1287, - 1295 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "BIOPSY", - 1227, - 1233 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "ESTROGEN ", - 1300, - 1309 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "HER2/NEU", - 7789, - 7797 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "1+", - 7804, - 7806 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "Density", - 5929, - 5936 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "density", - 6721, - 6728 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "breast invasive ductal carcinoma", - 6225, - 6257 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "Total Nottingham score", - 7066, - 7088 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "TUBULE FORMATION", - 595, - 611 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "LYMPHATIC INVASION", - 7163, - 7181 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "NUCLEAR PLEOMORPHISM", - 616, - 636 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "Ductal adenocarcinoma", - 6953, - 6974 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - "INVASIVE CARCINOMA", - 6697, - 6715 - ], - "meta": [ - null, - null, - null, - null - ] - }, - { - "row": [ - "===================================================================\nReport ID.....................354,ShF40YzRANkF\nPatient ID....................ShF40YzRANkF\nPatient Name..................Patient10\nPrincipal Date................20130111 1310\nRecord Type...................SP\n===================================================================\n[Report de-identified (Limited dataset compliant) by De-ID v.6.24.5.1]\n\n\nFINAL DIAGNOSIS:\nPART 1: BREAST, LEFT, 2 O'CLOCK, RADIOACTIVE SEED LOCALIZED SEGMENTAL\nMASTECTOMY\nA. INVASIVE INFILTRATING DUCTAL CARCINOMA.\nB. NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3,\nMITOTIC ACTIVITY 1; TOTAL SCORE: 7/9).\nC. INVASIVE TUMOR MEASURES 1.9 CM IN MAXIMUM DIMENSION.\nD. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN.\nE. DCIS IS PRESENT ADMIXED AND AWAY FROM INVASIVE CARCINOMA AND SPANS AN\nAREA OF APPROXIMATELY 0.3 CM.\nF. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.\nG. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA.\nH. INVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST SUPERIOR MARGIN.\nI. DCIS IS 0.2 CM FROM THE NEAREST SUPERIOR MARGIN.\nJ. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES.\nK. PREVIOUS BIOPSY SITE CHANGES.\nL. THE INVASIVE TUMOR CELLS TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE\nRECEPTORS AND NEGATIVE/1+ FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT\n***PATH-NUMBER[1] (12/5/12).\nPART 2: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 3: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2\nNO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE (1) LYMPH NODE (0/1).\nPART 4: BREAST, NEW LATERAL MARGIN, EXCISION\nBENIGN FIBROFATTY SOFT TISSUE.\n\n\nPathologist: Person117, M.D.\n** Report Electronically Signed Out **\nBy Pathologist: Person117, M.D.\n1/14/2013 18:17\nMy signature is attestation that I have personally reviewed the submitted\nmaterial(s) and the final diagnosis reflects that evaluation.\n_______________________________________________________________\nGROSS DESCRIPTION:\nThe specimen is received fresh in 4 parts:\nPart 1 is received labeled with the patient's name, initials CAP, and\n\"radioactive seed localized segmental mastectomy 7 o'clock margin map\". It\nconsists of 860.17 g, 7.2 cm medial to lateral, 6.3 cm anterior to posterior\nand 4.0 cm superior to inferior portion of oriented yellow lobulated adipose\ntissue. The specimen is inked according to orientation serially sectioned\nfrom medial to lateral into 13 slices. Sectioning reveals a 1.9 x 1.6 x 1.2\ncm tan-white, firm mass in slices 11 and 12. The mass is approximately 0.4 cm\nfrom the nearest superior margin, 0.5 cm from the nearest anterior margin, 1.0\ncm from the nearest inferior margin, 1.2 cm from the nearest lateral margin,\n1.5 cm from the nearest posterior margin and 5.0 cm from the nearest medial\nmargin. Embedded within the mass in slice 11 is a silver metallic radioactive\nseed (Rx #529600). Embedded within the mass in slice 12 is a silver metallic\nwing shaped biopsy clip. The remainder of the specimen is composed of\napproximately 95% yellow lobulated adipose tissue and 5% dense white fibrous\ntissue. Representative to include the mass in its entirety are submitted from\nmedial to lateral and an individual sections from anterior to posterior and\ninferior to superior as follows:\n1A-1B- slice 1, medial, perpendicular\n1C-1F- slice 11 (closest anterior, posterior, superior, inferior and lateral\nmargins to the mass)\n1G- slice 12, mass blocked out\n1H- slice 12, mirror image of mass\n1I- slice 3, fibrous tissue to include margins\n1J- slice 5, fibrous tissue to include margins\n1K- slice 7, fibrous tissue to include margins\n1L- slice 9, fibrous tissue to include margins\n1M-1Q- slice 13, lateral, perpendicular\nBlock 1-left breast tumor\nBlock 2-left breast normal\nGTBQA Study:\n1C-1F-full face tumor (slice 11)\n1C-1F-periphery\n1G-1H-full face tumor (slice12)\n1G-1H- full face section\nPhoto attached\nInking key:\nAnterior- orange\nPosterior- black\nSuperior- red\nInferior- green\nMedial- blue\nLateral- yellow\nCold Ischemic Time: 47 minutes.\nFormalin Exposure Time: 55 hours and 3 minutes.\nPart 2 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #1, Blue 1300\". It consists of a 4.2 x 2.1 x\n1.2 cm portion of yellow lobulated adipose tissue. Dissected from the adipose\ntissue is a 1.7 x 1.2 x 0.8 cm tan-pink possible lymph node. The possible\nlymph node is serially sectioned at 2 mm intervals and entirely submitted in\ncassettes 2A through 2B.\nFormalin exposure time: 57 hours and 2 minutes.\nPart 3 is received labeled with the patient's name, initials CAP, and \"left\naxillary sentinel node biopsy #2, not Blue 1300\". It consists of a 2.5 x 1.6\nx 0.6 cm portion of partially cauterized yellow lobulated adipose tissue.\nDissected from the adipose tissue is a 0.8 x 0.8 x 0.5 cm tan-pink possible\nlymph node. The possible lymph node is serially sectioned at 2 mm intervals\nand the specimen is entirely submitted as follows:\n3A- possible lymph node\n3B- surrounding adipose tissue\nFormalin exposure time: 57 hours and 2 minutes.\nPart 4 is received labeled with the patient's name, initials CAP, and \"new\nlateral margin\". It consists of an 11.1 g, a 6.0 x 3.7 x 1.8 cm portion of\nunoriented yellow lobulated fibroadipose tissue. The specimen is serially\nsectioned to reveal a cut surface composed of approximately 95% yellow\nlobulated adipose tissue and 5% densely fibrous tissue. No discrete masses or\nlesions are grossly identified. Representative sections are submitted in\ncassettes 4A through 4E.\nFormalin exposure time: 57 hours and 2 minutes.\nalo\nAXO1//AXO1/AXO1\nMICROSCOPIC:\nMicroscopic examination substantiates the above diagnosis.\ncaa\n\nThe following statement applies to all immunohistochemistry, Insitu\nHybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and\nImmunofluorescent Testing:\nThe testing was developed and its performance characteristics determined by\nthe Institution, as required by the CLIA\n'88 regulations. The testing has not been cleared or approved for the\nspecific use by the U.S. Food and Drug Administration, but the FDA has\ndetermined such approval is not necessary for clinical use.\nThis laboratory is certified under the Clinical Laboratory Improvement\nAmendments of 1988 (\"CLIA\") as qualified to perform high-complexity clinical\ntesting. Pursuant to the requirements of CLIA, ASR's used in this laboratory\nhave been established and verified for accuracy and precision. Additional\ninformation about this type of test is available upon request.\nCASE SYNOPSIS:\nSYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST\nLATERALITY: Right\nPROCEDURE: Segmental\nLOCATION: Not specified\nSIZE OF TUMOR: Maximum dimension invasive component: 19 mm\nMULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:\nNo\nTUMOR TYPE (invasive component):\nDuctal adenocarcinoma, NOS\nNOTTINGHAM SCORE: Nuclear grade: 3\nTubule formation: 3\nMitotic activity score: 1\nTotal Nottingham score: 7\nNottingham grade (1, 2, 3): 2\nANGIOLYMPHATIC INVASION: Yes\nDERMAL LYMPHATIC INVASION: Not applicable\nCALCIFICATION: No\nTUMOR TYPE, IN SITU: Solid\nSURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:\nNo\nDistance of invasive tumor to closest margin: 4 mm\nSURG MARGINS INVOLVED BY IN SITU COMPONENT:\nNo\nDistance of in situ disease to closest margin: 2 mm\nLYMPH NODES POSITIVE: 0\nLYMPH NODES EXAMINED: 2\nMETHOD(S) OF LYMPH NODE EXAMINATION:\nH/E stain\nSENTINEL NODE METASTASIS: No\nT STAGE, PATHOLOGIC: pT1c\nN STAGE MODIFIER: (sn)\nN STAGE, PATHOLOGIC: pN0\nM STAGE: Not applicable\nESTROGEN RECEPTORS: positive\nPROGESTERONE RECEPTORS: positive\nHER2/NEU: 1+\n--------------------------------------------------------\n\nPATIENT HISTORY:\nProcedure: Left segmental mastectomy, sentinel node biopsy\nClinical Findings Based On: Not provided\nNumber of Lesions: Not provided\nSite and Size Lesion 1: Not provided, Histology: Not provided\nOther Areas: Not provided\nNeoadjuvant Therapy: Not provided\nType of Neoadjuvant Therapy: Not provided\nPretherapy Size: Not provided\nComment: Not provided\nalo\nHISTO TISSUE SUMMARY/SLIDES REVIEWED:\nPart 1: RSL Left Segmental Mastectomy 2:00\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nH&E x 1 F\nH&E x 1 G\nH&E x 1 H\nH&E x 1 I\nH&E x 1 J\nH&E x 1 K\nH&E x 1 L\nH&E x 1 M\nH&E x 1 N\nH&E x 1 O\nH&E x 1 P\nH&E x 1 Q\nx 2 (none)\nPart 2: Left Axilla SNB #1\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 3: Left Axilla SNB #2\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nPart 4: New Lateral Margin\nTaken: 1/11/2013 13:10 Received: 1/11/2013 14:08\nStain/cnt Block\nH&E x 1 A\nH&E x 1 B\nH&E x 1 C\nH&E x 1 D\nH&E x 1 E\nTC1", - 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